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Fbxo6 F-box protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192351, updated on 7-May-2026
Official Symbol
Fbxo6provided by RGD
Official Full Name
F-box protein 6provided by RGD
Primary source
RGD:620418
See related
Ensembl:ENSRNOG00000009217 AllianceGenome:RGD:620418
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fbg2; Fbxo6b
Summary
Predicted to enable carbohydrate binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum quality control compartment. Orthologous to human FBXO6 (F-box protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Muscle (RPKM 233.8), Heart (RPKM 218.5) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Fbxo6 in Genome Data Viewer
Location:
5q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163859909..163865693, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158576729..158582520, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164956285..164962075, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Zhang YW, et al. Mol Cell, 2009 Aug 28. PMID 19716789, Free PMC Article
  2. A new subfamily of structurally related human F-box proteins. Ilyin GP, et al. Gene, 2002 Aug 21. PMID 12383498
  3. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. Yoshida Y, et al. J Biol Chem, 2003 Oct 31. PMID 12939278
  4. Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates. Yoshida Y, et al. EMBO Rep, 2005 Mar. PMID 15723043, Free PMC Article
  5. Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. Groisman B, et al. J Biol Chem, 2011 Jan 14. PMID 21062743, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum quality control compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum quality control compartment IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum quality control compartment ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
F-box only protein 6
Names
F-box only protein 6 b
F-box only protein 6b
F-box protein that recognizes sugar chains 2
F-box/G-domain protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138917.3 → NP_620272.3  F-box only protein 6

    See identical proteins and their annotated locations for NP_620272.3

    Status: PROVISIONAL

    Source sequence(s)
    AF393484
    UniProtKB/Swiss-Prot
    Q6P512, Q923V4
    UniProtKB/TrEMBL
    A6IU51
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 51
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    163859909..163865693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239374.5 → XP_006239436.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006239436.1

    UniProtKB/Swiss-Prot
    Q6P512, Q923V4
    UniProtKB/TrEMBL
    A6IU51
    Related
    ENSRNOP00000012301.4, ENSRNOT00000012301.6
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 51
    F-box-like; F-box-like

  2. XM_006239375.5 → XP_006239437.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006239437.1

    UniProtKB/Swiss-Prot
    Q6P512, Q923V4
    UniProtKB/TrEMBL
    A6IU51
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 51
    F-box-like; F-box-like

  3. XM_006239372.5 → XP_006239434.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006239434.1

    UniProtKB/Swiss-Prot
    Q6P512, Q923V4
    UniProtKB/TrEMBL
    A6IU51
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 51
    F-box-like; F-box-like

  4. XM_006239373.5 → XP_006239435.1  F-box only protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006239435.1

    UniProtKB/Swiss-Prot
    Q6P512, Q923V4
    UniProtKB/TrEMBL
    A6IU51
    Conserved Domains (2) summary
    pfam04300
    Location:70 → 248
    FBA; F-box associated region
    pfam12937
    Location:4 → 51
    F-box-like; F-box-like

  5. XM_063287150.1 → XP_063143220.1  F-box only protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q6P512, Q923V4
    UniProtKB/TrEMBL
    A6IU51
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923V4.1 GenPept UniProtKB/Swiss-Prot:Q923V4

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