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terfa telomeric repeat binding factor a [ Danio rerio (zebrafish) ]

Gene ID: 192316, updated on 23-Apr-2026
Official Symbol
terfaprovided by ZNC
Official Full Name
telomeric repeat binding factor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-38
See related
Ensembl:ENSDARG00000039302 AllianceGenome:ZFIN:ZDB-GENE-020419-38
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CHUNP6903; wu:fi15d05; wu:fi22b03; zgc:111909; zgc:114011
Summary
Enables telomeric DNA binding activity. Predicted to be involved in protein localization to chromosome, telomeric region; regulation of telomere maintenance; and telomere maintenance. Predicted to act upstream of or within telomere maintenance. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of shelterin complex. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human TERF2 (telomeric repeat binding factor 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See terfa in Genome Data Viewer
Location:
chromosome: 4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 4 NC_133179.1 (75764084..75787172, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 4 NC_007115.7 (77973874..77996958)

Chromosome 4 - NC_133179.1Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1, subunit 2 (beta) Neighboring gene uncharacterized LOC141381972 Neighboring gene ras-related protein Rab-19 Neighboring gene uncharacterized LOC141381978 Neighboring gene IKBKB interacting protein Neighboring gene uncharacterized LOC141381971 Neighboring gene cytoskeleton associated protein 4 Neighboring gene ADP-ribosylation factor GTPase activating protein 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA. Kim MJ, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33984809
  2. Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Zada D, et al. Nat Commun, 2019 Mar 5. PMID 30837464, Free PMC Article
  3. The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Hu X, et al. Biochimie, 2021 Nov. PMID 34214617
  4. Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Sorrells S, et al. Dis Model Mech, 2018 Feb 26. PMID 29419415, Free PMC Article
  5. Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration. Barthelaix A, et al. Theranostics, 2025. PMID 40756365, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA.
    Title: Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC111909, MGC114011, MGC192548

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric repeat DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric repeat DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of telomere maintenance via recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of telomeric D-loop disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protection from non-homologous end joining at telomere IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protection from non-homologous end joining at telomere IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in telomeric D-loop disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomeric loop formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of shelterin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
telomeric repeat binding factor a

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173243.2 → NP_775350.2  telomeric repeat binding factor a

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000004
    UniProtKB/TrEMBL
    A0A8N7UZT2, F1Q8U5, F1QRC8, Q4FZZ9
    Related
    ENSDARP00000057422.5, ENSDART00000057423.8
    Conserved Domains (3) summary
    smart00717
    Location:524 → 570
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:522 → 570
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133179.1 Reference GRCz12tu Primary Assembly

    Range
    75764084..75787172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073945545.1 → XP_073801646.1  telomeric repeat binding factor a isoform X8

    UniProtKB/TrEMBL
    A0AC58J598, Q8JGS4

  2. XM_073945547.1 → XP_073801648.1  telomeric repeat binding factor a isoform X12

    UniProtKB/TrEMBL
    A0AC58J594, Q8JGS4

  3. XM_073945546.1 → XP_073801647.1  telomeric repeat binding factor a isoform X10

    UniProtKB/TrEMBL
    A0AC58J592, Q8JGS4

  4. XM_068219509.1 → XP_068075610.1  telomeric repeat binding factor a isoform X4

    UniProtKB/TrEMBL
    A0AB32TNK0, Q4FZZ9

  5. XM_073945543.1 → XP_073801644.1  telomeric repeat binding factor a isoform X5

    UniProtKB/TrEMBL
    A0AC58J584, Q8JGS4

  6. XM_009301104.4 → XP_009299379.1  telomeric repeat binding factor a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B9A0, Q4FZZ9
    Conserved Domains (3) summary
    smart00717
    Location:559 → 605
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:557 → 605
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 202
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  7. XM_073945544.1 → XP_073801645.1  telomeric repeat binding factor a isoform X6

    UniProtKB/TrEMBL
    A0AC58J593, Q8JGS4

  8. XM_021474925.2 → XP_021330600.1  telomeric repeat binding factor a isoform X11

    UniProtKB/TrEMBL
    A0A8M9QAZ0, Q8JGS4
    Conserved Domains (2) summary
    cd11660
    Location:457 → 505
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  9. XM_068219510.1 → XP_068075611.1  telomeric repeat binding factor a isoform X9

    UniProtKB/TrEMBL
    A0AB32TQH7, Q8JGS4

  10. XM_021474924.2 → XP_021330599.1  telomeric repeat binding factor a isoform X7

    UniProtKB/TrEMBL
    A0A8M9Q073, Q8JGS4
    Conserved Domains (2) summary
    cd11660
    Location:493 → 541
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

  11. XM_068219508.1 → XP_068075609.1  telomeric repeat binding factor a isoform X3

    UniProtKB/TrEMBL
    A0AB32TM27, Q8JGS4

  12. XM_009301103.4 → XP_009299378.1  telomeric repeat binding factor a isoform X1

    UniProtKB/TrEMBL
    A0A8M3ART8, Q4FZZ9
    Conserved Domains (3) summary
    smart00717
    Location:560 → 606
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:558 → 606
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    cd00280
    Location:7 → 203
    TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
Nucleotide Protein Strain
Heading Accession and Version

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