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Ptma prothymosin alpha [ Mus musculus (house mouse) ]

Gene ID: 19231, updated on 19-Feb-2023

Summary

Official Symbol
Ptmaprovided by MGI
Official Full Name
prothymosin alphaprovided by MGI
Primary source
MGI:MGI:97803
See related
Ensembl:ENSMUSG00000026238 AllianceGenome:MGI:97803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thym
Summary
Enables histone binding activity. Acts upstream of or within histone exchange. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; extraembryonic component; and genitourinary system. Used to study polycystic kidney disease and pulmonary emphysema. Orthologous to human PTMA (prothymosin alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1626.5), CNS E14 (RPKM 884.0) and 25 other tissues See more
Orthologs
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Genomic context

See Ptma in Genome Data Viewer
Location:
1; 1 C5
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86454279..86458434)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86526557..86530712)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41907 Neighboring gene ribosomal protein L30, pseudogene 6 Neighboring gene phosphodiesterase 6D, cGMP-specific, rod, delta Neighboring gene COP9 signalosome subunit 7B Neighboring gene predicted gene, 41908

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102090, MGC103390

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone chaperone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone chaperone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360830.2NP_001347759.1  prothymosin alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158132
    Conserved Domains (1) summary
    pfam03247
    Location:253
    Prothymosin; Prothymosin/parathymosin family
  2. NM_001360831.2NP_001347760.1  prothymosin alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158132
    Conserved Domains (1) summary
    pfam03247
    Location:247
    Prothymosin; Prothymosin/parathymosin family
  3. NM_008972.4NP_032998.1  prothymosin alpha isoform 1

    See identical proteins and their annotated locations for NP_032998.1

    Status: VALIDATED

    Source sequence(s)
    AC158132
    Consensus CDS
    CCDS35649.1
    UniProtKB/Swiss-Prot
    P26350, Q3UQV6
    UniProtKB/TrEMBL
    Q0VGU2
    Related
    ENSMUSP00000044188.9, ENSMUST00000045897.15
    Conserved Domains (1) summary
    pfam03247
    Location:2110
    Prothymosin; Prothymosin/parathymosin family

RNA

  1. NR_153833.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158132
  2. NR_153834.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158132

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    86454279..86458434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)