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hdac1 histone deacetylase 1 [ Danio rerio (zebrafish) ]

Gene ID: 192302, updated on 5-Jul-2025
Official Symbol
hdac1provided by ZNC
Official Full Name
histone deacetylase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-32
See related
Ensembl:ENSDARG00000015427 AllianceGenome:ZFIN:ZDB-GENE-020419-32
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hdac-1; chunp6919; zgc:65818; wu:fb19h11; wu:fi06f03; zgc:101582; mp:zf637-2-001987
Summary
Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on secondary heart field specification. Acts upstream of or within several processes, including cardiac muscle cell proliferation; digestive system development; and nervous system development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of NuRD complex. Is expressed in immature eye; nervous system; pectoral fin; and pharyngeal arch. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See hdac1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 19 NC_133194.1 (32277852..32287811)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 19 NC_007130.7 (29808700..29818648)

Chromosome 19 - NC_133194.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 5b Neighboring gene uncharacterized LOC141379120 Neighboring gene MARCKS-like 1b Neighboring gene eukaryotic translation initiation factor 3, subunit I Neighboring gene taxilin alpha

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC101582

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables histone acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase activity, hydrolytic mechanism IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within convergent extension involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within facial nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rostrocaudal neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect secondary heart field specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
histone deacetylase 1
Names
col
colgate
NP_775343.1
XP_005159649.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173236.1NP_775343.1  histone deacetylase 1

    See identical proteins and their annotated locations for NP_775343.1

    Status: PROVISIONAL

    Source sequence(s)
    AF506201
    UniProtKB/TrEMBL
    Q8JIY7
    Related
    ENSDARP00000051798.4, ENSDART00000051799.6
    Conserved Domains (2) summary
    cd10010
    Location:5375
    HDAC1; Histone deacetylase 1 (HDAC1)
    PTZ00063
    Location:8406
    PTZ00063; histone deacetylase; Provisional

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133194.1 Reference GRCz12tu Primary Assembly

    Range
    32277852..32287811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159592.6XP_005159649.1  histone deacetylase 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8QIW0, A0A8M2B6N2
    Related
    ENSDARP00000155165.1
    Conserved Domains (2) summary
    cd10010
    Location:5375
    HDAC1; Histone deacetylase 1 (HDAC1)
    PTZ00063
    Location:8406
    PTZ00063; histone deacetylase; Provisional