U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nrbp1 nuclear receptor binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 192292, updated on 21-Apr-2024

Summary

Official Symbol
Nrbp1provided by MGI
Official Full Name
nuclear receptor binding protein 1provided by MGI
Primary source
MGI:MGI:2183436
See related
Ensembl:ENSMUSG00000029148 AllianceGenome:MGI:2183436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrbp; B230344L17Rik
Summary
Enables protein homodimerization activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular signal transduction. Located in perinuclear region of cytoplasm. Is expressed in cap mesenchyme; ovary; and renal interstitium. Orthologous to human NRBP1 (nuclear receptor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 58.6), duodenum adult (RPKM 52.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
5 B1; 5 17.27 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31398227..31408910)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31228089..31251566)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform Neighboring gene STARR-seq mESC enhancer starr_12768 Neighboring gene predicted gene 9970 Neighboring gene keratinocyte associated protein 3 Neighboring gene intraflagellar transport 172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31593577-31593686

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6961

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
NOT acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor-binding protein
Names
HLS7-interacting protein kinase
MLF1 adapter molecule

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347326.1NP_001334255.1  nuclear receptor-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC114619
    Consensus CDS
    CCDS84863.1
    UniProtKB/TrEMBL
    D3YUV1, Q3TCW5
    Related
    ENSMUSP00000143872.2, ENSMUST00000202576.4
  2. NM_147201.2NP_671734.1  nuclear receptor-binding protein isoform 2

    See identical proteins and their annotated locations for NP_671734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC114619
    Consensus CDS
    CCDS19180.1
    UniProtKB/Swiss-Prot
    Q8BL77, Q99J45
    UniProtKB/TrEMBL
    Q3TCW5
    Related
    ENSMUSP00000031034.6, ENSMUST00000031034.12
    Conserved Domains (2) summary
    smart00220
    Location:83325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14034
    Location:60334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31398227..31408910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)