Format

Send to:

Choose Destination

Tmlhe trimethyllysine hydroxylase, epsilon [ Mus musculus (house mouse) ]

Gene ID: 192289, updated on 26-Jul-2018

Summary

Official Symbol
Tmlheprovided by MGI
Official Full Name
trimethyllysine hydroxylase, epsilonprovided by MGI
Primary source
MGI:MGI:2180203
See related
Ensembl:ENSMUSG00000079834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TMLD; TMLH; Bbox2; D430017M14Rik
Annotation information
Annotation category: suggests misassembly
Orthologs

Genomic context

See Tmlhe in Genome Data Viewer
Location:
X; X
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X Unlocalized Scaffold NT_165789.2 (159604..334431)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X Unlocalized Scaffold NT_165789.2 (159647..334187)

NT_165789.2Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 7 Neighboring gene sprouty RTK signaling antagonist 3 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 pseudogene Neighboring gene Zf12 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC130426

Gene Ontology Provided by MGI

Process Evidence Code Pubs
carnitine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carnitine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
carnitine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
trimethyllysine dioxygenase, mitochondrial
Names
TML dioxygenase
TML hydroxylase
TML-alpha-ketoglutarate dioxygenase
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 2 (gamma-butyrobetaine hydroxylase)
epsilon-trimethyllysine 2-oxoglutarate dioxygenase
NP_620097.1
XP_006535917.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138758.2NP_620097.1  trimethyllysine dioxygenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_620097.1

    Status: VALIDATED

    Source sequence(s)
    AK052425, AK161724, CAAA01120074
    UniProtKB/Swiss-Prot
    Q91ZE0
    Related
    ENSMUSP00000111624.2, ENSMUST00000115964.2
    Conserved Domains (3) summary
    cd00250
    Location:142408
    CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
    TIGR02410
    Location:70419
    carnitine_TMLD; trimethyllysine dioxygenase
    pfam06155
    Location:54133
    DUF971; Protein of unknown function (DUF971)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NT_165789.2 Reference GRCm38.p4 C57BL/6J

    Range
    159604..334431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535854.3XP_006535917.1  trimethyllysine dioxygenase, mitochondrial isoform X1

    Conserved Domains (3) summary
    cd00250
    Location:142329
    CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
    TIGR02410
    Location:70340
    carnitine_TMLD; trimethyllysine dioxygenase
    pfam06155
    Location:54133
    DUF971; Protein of unknown function (DUF971)
Support Center