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Oas1a 2'-5' oligoadenylate synthetase 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 192281, updated on 3-Jun-2026
Official Symbol
Oas1aprovided by RGD
Official Full Name
2'-5' oligoadenylate synthetase 1Aprovided by RGD
Primary source
RGD:621760
See related
Ensembl:ENSRNOG00000001369 AllianceGenome:RGD:621760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oas1; Oas1g
Summary
Enables 2'-5'-oligoadenylate synthetase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of cytokine production; and regulation of innate immune response. Located in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 100. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 97.7), Lung (RPKM 85.8) and 9 other tissues See more
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Try the new Transcripts and proteins table
See Oas1a in Genome Data Viewer
Location:
12q16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41330423..41341130)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35669798..35680505)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41200680..41211393)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1D Neighboring gene uncharacterized LOC134481189 Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1H Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1F

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions. Truve E, et al. Biotechnology (N Y), 1993 Sep. PMID 7764002
  2. Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: effects of 17beta-estradiol on the regulation of OAS1g in both tissues. Maia CJ, et al. Mol Cell Biochem, 2008 Jul. PMID 18421422
  3. Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon. Wathelet M, et al. FEBS Lett, 1986 Feb 3. PMID 3753689
  4. Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase. Shiojiri S, et al. J Biochem, 1986 May. PMID 3754863
  5. (2'-5')Oligoadenylate synthetase in pig spleen: isolation and characterization. Shimizu N, et al. J Biochem, 1983 Nov. PMID 6654863

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OAS1g gene may be related to estrogen dependent pathways in rat mammary gland and prostate physiology.
    Title: Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: effects of 17beta-estradiol on the regulation of OAS1g in both tissues.
  2. Production of an isoform of 2'5'AS was induced following Leydig cells stimulation by the Sendai virus
    Title: Production of the antiviral proteins 2'5'oligoadenylate synthetase, PKR and Mx in interstitial cells and spermatogonia.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC93097

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2'-5'-oligoadenylate synthetase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2'-5'-oligoadenylate synthetase activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-27-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-27-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
2'-5'-oligoadenylate synthase 1A
Names
(2-5')oligo(A) synthase 1
(2-5')oligo(A) synthase 1A
(2-5')oligo(A) synthetase 1
2',5'-oligoadenylate synthetase 1, 40/46kDa
2'-5' oligoadenylate synthetase 1G
2'-5'-oligoadenylate synthase 1
2'-5'-oligoadenylate synthetase 1
2-5A synthase 1
2-5A synthase 1A
2-5A synthetase 1
25 oligoadenylate synthetase
NP_620268.2
XP_006249444.1
XP_063127107.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001436428.1 → NP_001423357.1  2'-5'-oligoadenylate synthase 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q05961
    UniProtKB/TrEMBL
    F7EEP6, Q5MYW5

  2. NM_138913.3 → NP_620268.2  2'-5'-oligoadenylate synthase 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q05961
    UniProtKB/TrEMBL
    A6J1H0
    Related
    ENSRNOP00000048411.4, ENSRNOT00000041741.6
    Conserved Domains (2) summary
    cd05400
    Location:27 → 167
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:165 → 349
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    41330423..41341130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249382.5 → XP_006249444.1  

    Related
    ENSRNOP00000040841.3, ENSRNOT00000048450.6
    Conserved Domains (2) summary
    cd05400
    Location:27 → 167
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:164 → 348
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

  2. XM_063271037.1 → XP_063127107.1  2'-5'-oligoadenylate synthase 1A isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05961.1 GenPept UniProtKB/Swiss-Prot:Q05961

Gene LinkOut

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