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Ubb ubiquitin B [ Rattus norvegicus (Norway rat) ]

Gene ID: 192255, updated on 13-Apr-2024

Summary

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Official Symbol
Ubbprovided by RGD
Official Full Name
ubiquitin Bprovided by RGD
Primary source
RGD:621562
See related
AllianceGenome:RGD:621562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tag and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process; positive regulation of protein monoubiquitination; and protein ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; energy homeostasis; and meiosis I. Predicted to be located in mitochondrion; neuron projection; and neuronal cell body. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBB (ubiquitin B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 9372.8), Brain (RPKM 6561.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q23
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47746923..47748628)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47247630..47249335)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48880231..48881896)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor co-repressor 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene centromere protein V Neighboring gene transmembrane p24 trafficking protein 4, pseudogene 1 Neighboring gene thymosin beta-4-like Neighboring gene small nucleolar RNA SNORA29 Neighboring gene transient receptor potential cation channel, subfamily V, member 2 Neighboring gene small nucleolar RNA, C/D box 49B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene expressions of ubiquitin and hsp70 following focal ischaemia in rat brain. Noga M, et al. Neuroreport, 1997 Mar 24. PMID 9175121
  2. Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene. Ryu KY, et al. Proc Natl Acad Sci U S A, 2008 Mar 11. PMID 18299572, Free PMC Article
  3. Polyubiquitin is a new phenotypic marker of contractile vascular smooth muscle cells. Adam PJ, et al. Cardiovasc Res, 1997 Feb. PMID 9074707
  4. Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats. Zhang Y, et al. J Cereb Blood Flow Metab, 2010 Mar. PMID 19844237, Free PMC Article
  5. Differential feeding-related regulation of ubiquitin and calbindin9kDa in rat duodenum. Hubbard MJ, et al. Biochim Biophys Acta, 1994 Jul 6. PMID 8031840

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mn(2+)-induced SNAT3 protein degradation and the dysregulation of Gln homeostasis in primary astrocyte cultures proceeds through the ubiquitin-mediated proteolytic system
    Title: Manganese-induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin-mediated proteolytic system.
  2. We conclude that activation of caspase-3 might be upstream of UBB(+1) formation and that excessive UBB(+1) could bind to beta secretase
    Title: Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fat pad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within female gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within female meiosis I ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hypothalamus gonadotrophin-releasing hormone neuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiosis I ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polyubiquitin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409092.1 → NP_001396021.1  polyubiquitin-B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P0CG51

  2. NM_138895.3 → NP_620250.3  polyubiquitin-B precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P0CG51

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    47746923..47748628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG51.1 GenPept UniProtKB/Swiss-Prot:P0CG51

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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