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Ubb ubiquitin B [ Rattus norvegicus (Norway rat) ]

Gene ID: 192255, updated on 3-Jun-2018
Official Symbol
Ubbprovided by RGD
Official Full Name
ubiquitin Bprovided by RGD
Primary source
RGD:621562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
mediates ATP-dependent degradation of denatured proteins [RGD, Feb 2006]
Expression
Biased expression in Testes (RPKM 9372.8), Brain (RPKM 6561.0) and 9 other tissues See more
Orthologs
See Ubb in Genome Data Viewer
Location:
10q23
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48880231..48881896)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (48664227..48665056)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene centromere protein V Neighboring gene hypothetical protein LOC691761 Neighboring gene thymosin beta-4 pseudogene Neighboring gene transient receptor potential cation channel, subfamily V, member 2

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Proteasome Degradation, organism-specific biosystem (from WikiPathways)
    Proteasome Degradation, organism-specific biosystem
    Proteasome Degradation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
fat pad development ISO
Inferred from Sequence Orthology
more info
 
female gonad development ISO
Inferred from Sequence Orthology
more info
 
female meiosis I ISO
Inferred from Sequence Orthology
more info
 
hypothalamus gonadotrophin-releasing hormone neuron development ISO
Inferred from Sequence Orthology
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
male meiosis I ISO
Inferred from Sequence Orthology
more info
 
mitochondrion transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
seminiferous tubule development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138895.2NP_620250.2  polyubiquitin-B precursor

    Status: VALIDATED

    Source sequence(s)
    BC078726, FM053084, FM072119, FN803398
    Conserved Domains (2) summary
    cd01803
    Location:153228
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    48880231..48881896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    46494897..46496578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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