Format

Send to:

Choose Destination

Ptgs1 prostaglandin-endoperoxide synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 19224, updated on 5-Jan-2022

Summary

Official Symbol
Ptgs1provided by MGI
Official Full Name
prostaglandin-endoperoxide synthase 1provided by MGI
Primary source
MGI:MGI:97797
See related
Ensembl:ENSMUSG00000047250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX1; Cox-1; Cox-3; PHS 1; Pghs1; PGHS-1
Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 9.1), bladder adult (RPKM 9.1) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ptgs1 in Genome Data Viewer
Location:
2 B; 2 24.19 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (36106758..36142287)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (36216742..36258593)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (36085946..36107789)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 18 Neighboring gene mitochondrial ribosome recycling factor Neighboring gene predicted gene, 46735 Neighboring gene olfactory receptor 334, pseudogene 1 Neighboring gene olfactory receptor 335, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin-endoperoxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables prostaglandin-endoperoxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cyclooxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostaglandin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prostaglandin G/H synthase 1
Names
PGH synthase 1
cyclooxygenase-1
prostaglandin H2 synthase 1
NP_032995.1
XP_006497853.1
XP_006497854.1
XP_006497857.1
XP_011237338.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008969.4NP_032995.1  prostaglandin G/H synthase 1 precursor

    See identical proteins and their annotated locations for NP_032995.1

    Status: REVIEWED

    Source sequence(s)
    AK159907, AW493573
    Consensus CDS
    CCDS15970.1
    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Related
    ENSMUSP00000059977.6, ENSMUST00000062069.6
    Conserved Domains (2) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    36106758..36142287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239036.4XP_011237338.1  prostaglandin G/H synthase 1 isoform X1

    See identical proteins and their annotated locations for XP_011237338.1

    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Conserved Domains (2) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_006497790.5XP_006497853.1  prostaglandin G/H synthase 1 isoform X1

    See identical proteins and their annotated locations for XP_006497853.1

    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Conserved Domains (2) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  3. XM_006497791.5XP_006497854.1  prostaglandin G/H synthase 1 isoform X1

    See identical proteins and their annotated locations for XP_006497854.1

    UniProtKB/Swiss-Prot
    P22437
    UniProtKB/TrEMBL
    Q543T1
    Conserved Domains (2) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  4. XM_006497794.5XP_006497857.1  prostaglandin G/H synthase 1 isoform X2

    Related
    ENSMUST00000149930.3
    Conserved Domains (2) summary
    cd09816
    Location:74560
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1754
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Support Center