Format

Send to:

Choose Destination

Rspo1 R-spondin 1 [ Mus musculus (house mouse) ]

Gene ID: 192199, updated on 12-Aug-2018

Summary

Official Symbol
Rspo1provided by MGI
Official Full Name
R-spondin 1provided by MGI
Primary source
MGI:MGI:2183426
See related
Ensembl:ENSMUSG00000028871 Vega:OTTMUSG00000009245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rspondin; R-spondin
Expression
Broad expression in ovary adult (RPKM 13.8), CNS E11.5 (RPKM 10.5) and 19 other tissues See more
Orthologs

Genomic context

See Rspo1 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (124986397..125009102)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (124663674..124686343)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40243 Neighboring gene predicted gene, 32371 Neighboring gene predicted gene, 38472 Neighboring gene guanine nucleotide binding protein-like 2 (nucleolar) Neighboring gene dynein, axonemal, light intermediate polypeptide 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of male germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
R-spondin-1
Names
R-spondin homolog
cristin-3
cysteine-rich and single thrombospondin domain-containing protein 3
mCristin-3
roof plate-specific spondin-1
thrombospondin type 1 domain containing gene Rspondin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138683.2NP_619624.2  R-spondin-1 precursor

    See identical proteins and their annotated locations for NP_619624.2

    Status: VALIDATED

    Source sequence(s)
    AB016768, AK132277
    Consensus CDS
    CCDS18633.1
    UniProtKB/Swiss-Prot
    Q9Z132
    UniProtKB/TrEMBL
    B1ASC1
    Related
    ENSMUSP00000030687.7, OTTMUSP00000009593, ENSMUST00000030687.7, OTTMUST00000020932
    Conserved Domains (3) summary
    cd00064
    Location:100142
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam15913
    Location:42144
    Furin-like_2; Furin-like repeat, cysteine-rich
    cl15278
    Location:151208
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    124986397..125009102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502862.2XP_006502925.1  R-spondin-1 isoform X1

    Conserved Domains (3) summary
    cd00064
    Location:3678
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam15771
    Location:126201
    DUF4700; Domain of unknown function (DUF4700)
    cl15278
    Location:87144
    TSP_1; Thrombospondin type 1 domain
Support Center