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Ash1l ASH1 like histone lysine methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 192195, updated on 3-Jun-2018
Official Symbol
Ash1lprovided by MGI
Official Full Name
ASH1 like histone lysine methyltransferaseprovided by MGI
Primary source
MGI:MGI:2183158
See related
Ensembl:ENSMUSG00000028053 Vega:OTTMUSG00000047367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ash1; Kmt2h; 8030453L17Rik; E430018P19Rik
Expression
Ubiquitous expression in bladder adult (RPKM 8.0), cerebellum adult (RPKM 8.0) and 28 other tissues See more
Orthologs
See Ash1l in Genome Data Viewer
Location:
3; 3 F1
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (88950492..89079375)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (88769734..88883297)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene gon-4-like (C.elegans) Neighboring gene predicted gene, 40091 Neighboring gene misato 1, mitochondrial distribution and morphology regulator Neighboring gene death associated protein 3 Neighboring gene RUN and SH3 domain containing 1 Neighboring gene farnesyl diphosphate synthetase

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Gene trapped (1) 
  • Targeted (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
histone methyltransferase activity (H3-K36 specific) ISO
Inferred from Sequence Orthology
more info
 
histone methyltransferase activity (H3-K4 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K36 dimethylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-K4 methylation IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
sebaceous gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
tarsal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
uterine gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
uterus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
histone-lysine N-methyltransferase ASH1L
Names
ASH1-like protein
absent small and homeotic disks protein 1 homolog
absent, small, or homeotic discs 1
ash1 (absent, small, or homeotic)-like
chromatin remodeling factor
probable histone-lysine N-methyltransferase ASH1L
NP_619620.3
XP_006501204.1
XP_006501205.1
XP_017174988.1
XP_017174989.1
XP_017174991.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138679.5NP_619620.3  histone-lysine N-methyltransferase ASH1L

    See identical proteins and their annotated locations for NP_619620.3

    Status: VALIDATED

    Source sequence(s)
    AK031724, AK033177, AK153783, BC052194, CF167627, CK627544
    Consensus CDS
    CCDS17487.1
    UniProtKB/Swiss-Prot
    Q99MY8
    Related
    ENSMUSP00000088451.4, ENSMUST00000090933.4
    Conserved Domains (5) summary
    cd05525
    Location:24322537
    Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
    smart00570
    Location:20822133
    AWS; associated with SET domains
    smart00317
    Location:21362256
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd04717
    Location:26542788
    BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
    cd15548
    Location:25752617
    PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    88950492..89079375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501142.2XP_006501205.1  histone-lysine N-methyltransferase ASH1L isoform X1

    See identical proteins and their annotated locations for XP_006501205.1

    UniProtKB/Swiss-Prot
    Q99MY8
    Conserved Domains (5) summary
    cd05525
    Location:24322537
    Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
    smart00570
    Location:20822133
    AWS; associated with SET domains
    smart00317
    Location:21362256
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd04717
    Location:26542788
    BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
    cd15548
    Location:25752617
    PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
  2. XM_006501141.2XP_006501204.1  histone-lysine N-methyltransferase ASH1L isoform X1

    See identical proteins and their annotated locations for XP_006501204.1

    UniProtKB/Swiss-Prot
    Q99MY8
    Related
    ENSMUSP00000140251.1, OTTMUSP00000067155, ENSMUST00000186583.6, OTTMUST00000122389
    Conserved Domains (5) summary
    cd05525
    Location:24322537
    Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
    smart00570
    Location:20822133
    AWS; associated with SET domains
    smart00317
    Location:21362256
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd04717
    Location:26542788
    BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
    cd15548
    Location:25752617
    PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
  3. XM_017319499.1XP_017174988.1  histone-lysine N-methyltransferase ASH1L isoform X2

  4. XM_017319500.1XP_017174989.1  histone-lysine N-methyltransferase ASH1L isoform X3

  5. XM_017319502.1XP_017174991.1  histone-lysine N-methyltransferase ASH1L isoform X4

RNA

  1. XR_001783666.1 RNA Sequence

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