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Btnl10 butyrophilin-like 10 [ Mus musculus (house mouse) ]

Gene ID: 192194, updated on 27-Feb-2024

Summary

Official Symbol
Btnl10provided by MGI
Official Full Name
butyrophilin-like 10provided by MGI
Primary source
MGI:MGI:2182073
See related
Ensembl:ENSMUSG00000020490 AllianceGenome:MGI:2182073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Butr1; BUTR-1
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in liver lobe. Orthologous to several human genes including BTNL10 (butyrophilin like 10) and BTN3A2 (butyrophilin subfamily 3 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 10.9), liver E14 (RPKM 9.9) and 3 other tissues See more
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Genomic context

See Btnl10 in Genome Data Viewer
Location:
11 B1.3; 11 36.37 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58808703..58817791)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58917877..58926965)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 39 Neighboring gene STARR-positive B cell enhancer ABC_E2990 Neighboring gene predicted gene 12257 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58741489-58741672 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58741803-58741956 Neighboring gene STARR-positive B cell enhancer ABC_E8409 Neighboring gene ring finger protein 187 Neighboring gene predicted gene, 51864 Neighboring gene STARR-positive B cell enhancer ABC_E3954 Neighboring gene H2B clustered histone 27

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
butyrophilin-like protein 10
Names
butyrophilin related 1
butyrophilin-like protein BUTR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363414.1NP_001350343.1  butyrophilin-like protein 10 variant 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AK143638, AL662809
    Consensus CDS
    CCDS88163.1
    Related
    ENSMUSP00000063279.7, ENSMUST00000069941.13
    Conserved Domains (3) summary
    cd05713
    Location:47146
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    cl02614
    Location:301471
    SPRY; SPRY domain
    cl11960
    Location:151229
    Ig; Immunoglobulin domain
  2. NM_138678.2NP_619619.2  butyrophilin-like protein 10 variant 2 precursor

    See identical proteins and their annotated locations for NP_619619.2

    Status: VALIDATED

    Source sequence(s)
    AL662809
    Consensus CDS
    CCDS24753.1
    UniProtKB/Swiss-Prot
    A2AB75, Q8C0U8, Q9JK39
    UniProtKB/TrEMBL
    A0A0R4J1C6
    Related
    ENSMUSP00000020792.6, ENSMUST00000020792.12
    Conserved Domains (3) summary
    cd05713
    Location:47146
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:39145
    IG_like; Immunoglobulin like
    cl11960
    Location:152231
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58808703..58817791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532533.3XP_006532596.1  butyrophilin-like protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006532596.1

    UniProtKB/Swiss-Prot
    Q9JK39
    Conserved Domains (3) summary
    cd05713
    Location:47146
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    cl02614
    Location:301471
    SPRY; SPRY domain
    cl11960
    Location:151229
    Ig; Immunoglobulin domain
  2. XM_006532534.3XP_006532597.1  butyrophilin-like protein 10 isoform X2

    Conserved Domains (3) summary
    cd05713
    Location:47146
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    pfam13765
    Location:303351
    PRY; SPRY-associated domain
    cl11960
    Location:151229
    Ig; Immunoglobulin domain
  3. XM_011248809.2XP_011247111.1  butyrophilin-like protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J1C6
    Conserved Domains (2) summary
    cd05713
    Location:47146
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    cl11960
    Location:151229
    Ig; Immunoglobulin domain
  4. XM_006532535.5XP_006532598.1  butyrophilin-like protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A0R4J1C6
    Conserved Domains (2) summary
    cd05713
    Location:47146
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    cl11960
    Location:151229
    Ig; Immunoglobulin domain