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Nadk NAD kinase [ Mus musculus (house mouse) ]

Gene ID: 192185, updated on 5-Mar-2024

Summary

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Official Symbol
Nadkprovided by MGI
Official Full Name
NAD kinaseprovided by MGI
Primary source
MGI:MGI:2183149
See related
Ensembl:ENSMUSG00000029063 AllianceGenome:MGI:2183149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4432404C02Rik
Summary
Predicted to enable NAD+ kinase activity. Predicted to be involved in NADP biosynthetic process and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 138.3), liver adult (RPKM 72.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 86.44 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155646838..155675458)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155562381..155591001)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12263 Neighboring gene transmembrane protein 52 Neighboring gene guanine nucleotide binding protein (G protein), beta 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12266 Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene STARR-positive B cell enhancer ABC_E3559 Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene cyclin dependent kinase 11B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural and functional characterization of human NAD kinase. Lerner F, et al. Biochem Biophys Res Commun, 2001 Oct 19. PMID 11594753
  2. Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression. Tavtigian SV, et al. Mol Biol Cell, 1994 Mar. PMID 8049528, Free PMC Article
  3. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article
  4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (6) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC7589

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NADP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
NAD kinase
Names
Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)
poly(P)/ATP NAD kinase
NP_001153109.1
NP_001342528.1
NP_619612.2
XP_006538725.1
XP_006538726.1
XP_006538728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159637.1 → NP_001153109.1  NAD kinase isoform 1

    See identical proteins and their annotated locations for NP_001153109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA197692, AK147917, AW455445, BE950056, BF453238, BF682935, CJ166231
    Consensus CDS
    CCDS19031.1
    UniProtKB/Swiss-Prot
    P58058, Q3TCP7
    UniProtKB/TrEMBL
    Q3TN62, Q3UGI1
    Related
    ENSMUSP00000101238.4, ENSMUST00000105613.10
    Conserved Domains (1) summary
    cl28462
    Location:96 → 429
    pnk; bifunctional NADP phosphatase/NAD kinase

  2. NM_001355599.1 → NP_001342528.1  NAD kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK147917, BB869695, BE950056, BP767626, BY202795, CF916286, CK334104, DV043414
    UniProtKB/TrEMBL
    A2A9P2
    Related
    ENSMUSP00000101237.2, ENSMUST00000105612.2
    Conserved Domains (1) summary
    cl28462
    Location:9 → 342
    pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional

  3. NM_138671.3 → NP_619612.2  NAD kinase isoform 1

    See identical proteins and their annotated locations for NP_619612.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK147917, BE950056, BP767626, BY154310, CF916286, CK334104, DV043414
    Consensus CDS
    CCDS19031.1
    UniProtKB/Swiss-Prot
    P58058, Q3TCP7
    UniProtKB/TrEMBL
    Q3TN62, Q3UGI1
    Related
    ENSMUSP00000030939.8, ENSMUST00000030939.14
    Conserved Domains (1) summary
    cl28462
    Location:96 → 429
    pnk; bifunctional NADP phosphatase/NAD kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155646838..155675458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538665.4 → XP_006538728.1  NAD kinase isoform X2

    Conserved Domains (1) summary
    cl01255
    Location:98 → 310
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. XM_006538662.5 → XP_006538725.1  NAD kinase isoform X1

    See identical proteins and their annotated locations for XP_006538725.1

    UniProtKB/Swiss-Prot
    P58058, Q3TCP7
    UniProtKB/TrEMBL
    Q3TN62, Q3UGI1
    Conserved Domains (1) summary
    cl28462
    Location:96 → 429
    pnk; bifunctional NADP phosphatase/NAD kinase

  3. XM_006538663.5 → XP_006538726.1  NAD kinase isoform X1

    See identical proteins and their annotated locations for XP_006538726.1

    UniProtKB/Swiss-Prot
    P58058, Q3TCP7
    UniProtKB/TrEMBL
    Q3TN62, Q3UGI1
    Conserved Domains (1) summary
    cl28462
    Location:96 → 429
    pnk; bifunctional NADP phosphatase/NAD kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58058.2 GenPept UniProtKB/Swiss-Prot:P58058

Gene LinkOut

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