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Flna filamin, alpha [ Mus musculus (house mouse) ]

Gene ID: 192176, updated on 8-Jul-2018
Official Symbol
Flnaprovided by MGI
Official Full Name
filamin, alphaprovided by MGI
Primary source
MGI:MGI:95556
See related
Ensembl:ENSMUSG00000031328 Vega:OTTMUSG00000016503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fln1; Dilp2; ABP-280; GENA 379; filamin-1; F730004A14Rik
Expression
Broad expression in bladder adult (RPKM 809.2), ovary adult (RPKM 279.4) and 17 other tissues See more
Orthologs
See Flna in Genome Data Viewer
Location:
X A7.3; X 37.89 cM
Exon count:
49
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (74223461..74249852, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71468800..71491873, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3, pseudogene 2 Neighboring gene transketolase-like 1 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene emerin Neighboring gene small nucleolar RNA, H/ACA box 70 Neighboring gene ribosomal protein L10

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Rac GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Ral GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Rho GTPase binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
actin binding TAS
Traceable Author Statement
more info
PubMed 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
mu-type opioid receptor binding ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin crosslink formation ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium assembly ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
 
early endosome to late endosome transport IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of Sertoli cell barrier ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
formation of radial glial scaffolds ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
protein localization to bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
receptor clustering ISO
Inferred from Sequence Orthology
more info
 
regulation of actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane repolarization during atrial cardiac muscle cell action potential IC
Inferred by Curator
more info
PubMed 
regulation of membrane repolarization during cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
semaphorin-plexin signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Myb complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
actin filament ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
actin filament bundle IDA
Inferred from Direct Assay
more info
PubMed 
apical dendrite ISO
Inferred from Sequence Orthology
more info
 
brush border IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with filamentous actin ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
filamin-A
Names
actin-binding protein 280
dilated pupils 2
endothelial actin-binding protein
non-muscle filamin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290421.1NP_001277350.1  filamin-A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL807376
    Conserved Domains (2) summary
    smart00557
    Location:13881477
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:12071290
    Filamin; Filamin/ABP280 repeat
  2. NM_010227.3NP_034357.2  filamin-A isoform 1

    See identical proteins and their annotated locations for NP_034357.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL807376
    Consensus CDS
    CCDS41018.1
    UniProtKB/TrEMBL
    B7FAU9
    Related
    ENSMUSP00000098997.2, ENSMUST00000101454.8
    Conserved Domains (4) summary
    smart00033
    Location:172264
    CH; Calponin homology domain
    smart00557
    Location:20392128
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:44148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:18581941
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    74223461..74249852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247549.2XP_011245851.1  filamin-A isoform X2

    See identical proteins and their annotated locations for XP_011245851.1

    UniProtKB/TrEMBL
    B7FAU9
    Related
    ENSMUSP00000109938.1, OTTMUSP00000017781, ENSMUST00000114299.7, OTTMUST00000039862
    Conserved Domains (4) summary
    smart00033
    Location:172264
    CH; Calponin homology domain
    smart00557
    Location:20392128
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:44148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:18581941
    Filamin; Filamin/ABP280 repeat
  2. XM_006527911.3XP_006527974.1  filamin-A isoform X1

    See identical proteins and their annotated locations for XP_006527974.1

    UniProtKB/Swiss-Prot
    Q8BTM8
    Related
    ENSMUSP00000033699.6, OTTMUSP00000017782, ENSMUST00000033699.12, OTTMUST00000039863
    Conserved Domains (4) summary
    smart00033
    Location:172264
    CH; Calponin homology domain
    smart00557
    Location:20472136
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:44148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:18661949
    Filamin; Filamin/ABP280 repeat
  3. XM_017318433.1XP_017173922.1  filamin-A isoform X3

    Conserved Domains (2) summary
    smart00557
    Location:13881477
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:12071290
    Filamin; Filamin/ABP280 repeat

RNA

  1. XR_001782741.1 RNA Sequence

    Related
    ENSMUST00000144429.7, OTTMUST00000039861
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