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Sardh sarcosine dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 192166, updated on 31-Jan-2019

Summary

Official Symbol
Sardhprovided by MGI
Official Full Name
sarcosine dehydrogenaseprovided by MGI
Primary source
MGI:MGI:2183102
See related
Ensembl:ENSMUSG00000009614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in liver adult (RPKM 211.5), kidney adult (RPKM 72.0) and 2 other tissues See more
Orthologs

Genomic context

See Sardh in Genome Data Viewer
Location:
2; 2 A3
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (27188393..27248332, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (27044902..27102332, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene dopamine beta hydroxylase, opposite strand Neighboring gene dopamine beta hydroxylase Neighboring gene vav 2 oncogene Neighboring gene bromodomain containing 3, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6279

Gene Ontology Provided by MGI

Function Evidence Code Pubs
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
folic acid binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcosine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcosine dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
sarcosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tetrahydrofolate interconversion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sarcosine dehydrogenase, mitochondrial
NP_619606.1
XP_006497851.1
XP_006497852.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138665.2NP_619606.1  sarcosine dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_619606.1

    Status: VALIDATED

    Source sequence(s)
    AK163515, AL731552, AW495221
    Consensus CDS
    CCDS15826.1
    UniProtKB/Swiss-Prot
    Q99LB7
    UniProtKB/TrEMBL
    Q3TWI2
    Related
    ENSMUSP00000099950.3, ENSMUST00000102886.9
    Conserved Domains (5) summary
    COG0404
    Location:480917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:490799
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:808872
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:431486
    FAO_M; FAD dependent oxidoreductase central domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    27188393..27248332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497789.3XP_006497852.1  sarcosine dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006497852.1

    UniProtKB/Swiss-Prot
    Q99LB7
    UniProtKB/TrEMBL
    Q3TWI2
    Conserved Domains (5) summary
    COG0404
    Location:480917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:490799
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:808872
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:431486
    FAO_M; FAD dependent oxidoreductase central domain
  2. XM_006497788.3XP_006497851.1  sarcosine dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006497851.1

    UniProtKB/Swiss-Prot
    Q99LB7
    UniProtKB/TrEMBL
    Q3TWI2
    Conserved Domains (5) summary
    COG0404
    Location:480917
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:64448
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:490799
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:808872
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:431486
    FAO_M; FAD dependent oxidoreductase central domain
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