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Prpf8 pre-mRNA processing factor 8 [ Mus musculus (house mouse) ]

Gene ID: 192159, updated on 26-Sep-2022

Summary

Official Symbol
Prpf8provided by MGI
Official Full Name
pre-mRNA processing factor 8provided by MGI
Primary source
MGI:MGI:2179381
See related
Ensembl:ENSMUSG00000020850 AllianceGenome:MGI:2179381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prp8; Sfprp8l; DBF3/PRP8; D11Bwg0410e
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; pre-mRNA intronic binding activity; and snRNA binding activity. Predicted to be involved in cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; and spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of U2-type spliceosomal complex and spliceosomal snRNP complex. Is expressed in several structures, including central nervous system; gonad; and sensory organ. Used to study retinitis pigmentosa 13. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Orthologous to human PRPF8 (pre-mRNA processing factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 48.5), whole brain E14.5 (RPKM 44.4) and 28 other tissues See more
Orthologs
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Genomic context

See Prpf8 in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75377603..75400273)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75486777..75509447)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Mir22 host gene (non-protein coding) Neighboring gene microRNA 22 Neighboring gene TLC domain containing 2 Neighboring gene Rab interacting lysosomal protein Neighboring gene scavenger receptor class F, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U5 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal-dependent deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA intronic binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in spliceosomal tri-snRNP complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
 
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U5 snRNP ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of small nuclear ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pre-mRNA-processing-splicing factor 8
Names
splicing factor Prp8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138659.2NP_619600.2  pre-mRNA-processing-splicing factor 8

    See identical proteins and their annotated locations for NP_619600.2

    Status: VALIDATED

    Source sequence(s)
    AK041017, AK144232, BP757620, BU510116, CB558040, CJ120731, CK636594, CN530184, CO426130, CV561799
    Consensus CDS
    CCDS25048.1
    UniProtKB/Swiss-Prot
    Q8K001, Q99PV0
    UniProtKB/TrEMBL
    A0A6P5QR08, A0A8C6HYI7, Q3UNG1
    Related
    ENSMUSP00000018449.5, ENSMUST00000018449.11
    Conserved Domains (1) summary
    COG5178
    Location:12335
    PRP8; U5 snRNP spliceosome subunit [RNA processing and modification]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75377603..75400273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)