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Sftpb surfactant protein B [ Rattus norvegicus (Norway rat) ]

Gene ID: 192155, updated on 18-Apr-2019

Summary

Official Symbol
Sftpbprovided by RGD
Official Full Name
surfactant protein Bprovided by RGD
Primary source
RGD:621700
See related
Ensembl:ENSRNOG00000010761
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sp-b
Summary
acts to lower surface tension in lung alveoli [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 5044.5) See more
Orthologs

Genomic context

See Sftpb in Genome Data Viewer
Location:
4q31
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100166855..100175941)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (164937638..164946703)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene atonal bHLH transcription factor 8 Neighboring gene S-formylglutathione hydrolase-like Neighboring gene ubiquitin specific peptidase 39 Neighboring gene hypothetical protein LOC691113 Neighboring gene transmembrane protein 150A Neighboring gene ring finger protein 181

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of liquid surface tension TAS
Traceable Author Statement
more info
PubMed 
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
response to epidermal growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
response to growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
alveolar lamellar body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alveolar lamellar body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pulmonary surfactant-associated protein B
Names
pulmonary surfactant-associated proteolipid SPL(Phe)
surfactant associated protein B
surfactant, pulmonary-associated protein B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138842.1NP_620197.1  pulmonary surfactant-associated protein B precursor

    See identical proteins and their annotated locations for NP_620197.1

    Status: PROVISIONAL

    Source sequence(s)
    X14778
    UniProtKB/Swiss-Prot
    P22355
    Related
    ENSRNOP00000014505.4, ENSRNOT00000014505.7
    Conserved Domains (4) summary
    smart00741
    Location:65141
    SapB; Saposin (B) Domains
    pfam03489
    Location:110141
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:67101
    SapB_1; Saposin-like type B, region 1
    cl02494
    Location:2959
    SapA; Saposin A-type domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    100166855..100175941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236657.3XP_006236719.1  pulmonary surfactant-associated protein B isoform X1

    Conserved Domains (4) summary
    smart00741
    Location:65141
    SapB; Saposin (B) Domains
    pfam03489
    Location:110141
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:67101
    SapB_1; Saposin-like type B, region 1
    cl02494
    Location:2959
    SapA; Saposin A-type domain

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    93513449..93522486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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