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Hip1 huntingtin interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192154, updated on 17-Nov-2020

Summary

Official Symbol
Hip1provided by RGD
Official Full Name
huntingtin interacting protein 1provided by RGD
Primary source
RGD:620305
See related
Ensembl:ENSRNOG00000001448
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
human homolog binds clathrin and the clathrin adaptor AP2; may play a role in clathrin-mediated endocytosis [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 168.4), Lung (RPKM 147.0) and 9 other tissues See more
Orthologs

Genomic context

See Hip1 in Genome Data Viewer
Location:
12q12
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24180795..24315373)
106 current Rn_Celera (GCF_000002265.2) 12 AC_000080.1 (22895802..23030274)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (26178145..26312676)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352436 Neighboring gene similar to ribosomal protein S13 Neighboring gene uncharacterized LOC102548966 Neighboring gene POM121 transmembrane nucleoporin Neighboring gene NOP2/Sun RNA methyltransferase 5 Neighboring gene tripartite motif-containing 50

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
clathrin binding ISO
Inferred from Sequence Orthology
more info
 
clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin light chain binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
NOT phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin coat assembly IDA
Inferred from Direct Assay
more info
PubMed 
clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
endocytosis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynapse IDA
Inferred from Direct Assay
more info
PubMed 
presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
huntingtin-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100475.1NP_001093945.1  huntingtin-interacting protein 1

    See identical proteins and their annotated locations for NP_001093945.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    G3V8Y8
    Related
    ENSRNOP00000031153.4, ENSRNOT00000030497.4
    Conserved Domains (5) summary
    smart00307
    Location:8071005
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:37308
    ANTH; ANTH domain
    pfam07926
    Location:433550
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam14335
    Location:336441
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:482572
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    24180795..24315373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249098.3XP_006249160.1  huntingtin-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006249160.1

    Conserved Domains (4) summary
    smart00307
    Location:8151013
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:37308
    ANTH; ANTH domain
    pfam14335
    Location:336441
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:482580
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  2. XM_006249100.3XP_006249162.1  huntingtin-interacting protein 1 isoform X4

    Conserved Domains (4) summary
    smart00307
    Location:781979
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:7274
    ANTH; ANTH domain
    pfam14335
    Location:302407
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:448546
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  3. XM_006249099.3XP_006249161.1  huntingtin-interacting protein 1 isoform X3

    Conserved Domains (4) summary
    smart00307
    Location:785983
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:11278
    ANTH; ANTH domain
    pfam14335
    Location:306411
    DUF4391; Domain of unknown function (DUF4391)
    pfam16515
    Location:452550
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  4. XM_017598252.1XP_017453741.1  huntingtin-interacting protein 1 isoform X1

  5. XM_017598253.1XP_017453742.1  huntingtin-interacting protein 1 isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    22895802..23030274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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