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Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 192113, updated on 11-Apr-2024

Summary

Official Symbol
Atp12aprovided by MGI
Official Full Name
ATPase, H+/K+ transporting, nongastric, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:1926943
See related
Ensembl:ENSMUSG00000022229 AllianceGenome:MGI:1926943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cHKA; Atp1al1; HKalpha2
Summary
Predicted to enable P-type potassium:proton transporter activity and P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within potassium ion homeostasis and regulation of pH. Located in basolateral plasma membrane. Is expressed in several structures, including gut; metanephros; pituitary gland; reproductive system; and thymus. Orthologous to human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward colon adult (RPKM 53.7) See more
Orthologs
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Genomic context

Location:
14 C3; 14 28.19 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56602525..56626008)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56364669..56388551)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene granzyme B Neighboring gene high mobility group protein B1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56915695-56915848 Neighboring gene STARR-seq mESC enhancer starr_36795 Neighboring gene predicted gene, 32454 Neighboring gene ring finger protein 17 Neighboring gene family with sequence similarity 54, member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC124416

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type potassium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to P-type potassium:proton transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables P-type potassium:proton transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables P-type sodium:potassium-exchanging transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables P-type sodium:potassium-exchanging transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to metal ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium-transporting ATPase alpha chain 2
Names
ATPase H+K+-transporting, alpha 2
HK alpha 2
non-gastric H(+)/K(+) ATPase subunit alpha
non-gastric Na(+)/K(+) ATPase subunit alpha
proton pump
sodium pump
NP_619593.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138652.2NP_619593.2  potassium-transporting ATPase alpha chain 2

    See identical proteins and their annotated locations for NP_619593.2

    Status: VALIDATED

    Source sequence(s)
    BC109011, BY663985
    Consensus CDS
    CCDS27148.1
    UniProtKB/Swiss-Prot
    Q32MR8, Q8VHY2, Q9Z1W8
    Related
    ENSMUSP00000007340.3, ENSMUST00000007340.4
    Conserved Domains (1) summary
    TIGR01106
    Location:401035
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56602525..56626008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)