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Pten phosphatase and tensin homolog [ Mus musculus (house mouse) ]

Gene ID: 19211, updated on 31-Jan-2023

Summary

Official Symbol
Ptenprovided by MGI
Official Full Name
phosphatase and tensin homologprovided by MGI
Primary source
MGI:MGI:109583
See related
Ensembl:ENSMUSG00000013663 AllianceGenome:MGI:109583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEP1; MMAC1; PTENbeta; 2310035O07Rik; A130070J02Rik; B430203M17Rik
Summary
This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 14.6), cortex adult (RPKM 12.9) and 28 other tissues See more
Orthologs
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Genomic context

See Pten in Genome Data Viewer
Location:
19 C1; 19 28.14 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32734977..32803560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32757577..32826160)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene killin, p53-regulated DNA replication inhibitor pseudogene Neighboring gene predicted gene, 36774 Neighboring gene predicted gene, 36914 Neighboring gene predicted gene, 36860

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC183880

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to decreased oxygen levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inositol phosphate catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in inositol phosphate dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in localization ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maternal behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prostate gland growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cellular component size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of macrophage apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhythmic synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Names
PTENepsilon
mitochondrial PTENalpha
mutated in multiple advanced cancers 1
NP_032986.1
XP_006526832.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008960.2NP_032986.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    See identical proteins and their annotated locations for NP_032986.1

    Status: REVIEWED

    Source sequence(s)
    AK138025, BU701098, CK616227, U92437
    Consensus CDS
    CCDS29753.1
    UniProtKB/Swiss-Prot
    O08586, Q542G1
    UniProtKB/TrEMBL
    A0A6G7SF19, A0A8C6I768, Q3UUT8
    Related
    ENSMUSP00000013807.8, ENSMUST00000013807.8
    Conserved Domains (2) summary
    cd14509
    Location:24181
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:188349
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    32734977..32803560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526769.3XP_006526832.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    Conserved Domains (2) summary
    pfam10409
    Location:55216
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:148
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177096.2: Suppressed sequence

    Description
    NM_177096.2: This RefSeq was temporarily suppressed because it is suspected to be 3' UTR sequence of a splice variant of the Pten gene (GeneID:19211).