Format

Send to:

Choose Destination

Pten phosphatase and tensin homolog [ Mus musculus (house mouse) ]

Gene ID: 19211, updated on 10-Dec-2019

Summary

Official Symbol
Ptenprovided by MGI
Official Full Name
phosphatase and tensin homologprovided by MGI
Primary source
MGI:MGI:109583
See related
Ensembl:ENSMUSG00000013663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEP1; MMAC1; AI463227; PTENbeta; 2310035O07Rik; A130070J02Rik; B430203M17Rik
Summary
This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 14.6), cortex adult (RPKM 12.9) and 28 other tissues See more
Orthologs

Genomic context

See Pten in Genome Data Viewer
Location:
19 C1; 19 28.14 cM
Exon count:
10
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32757577..32826160)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (32832067..32900650)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene killin, p53-regulated DNA replication inhibitor pseudogene Neighboring gene predicted gene, 36774 Neighboring gene predicted gene, 36914 Neighboring gene predicted gene, 36860

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC183880

Gene Ontology Provided by MGI

Function Evidence Code Pubs
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to decreased oxygen levels IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol phosphate dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
male mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
negative regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
presynaptic membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostate gland growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cellular component size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Names
mitochondrial PTENalpha
mutated in multiple advanced cancers 1
NP_032986.1
XP_006526832.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008960.2NP_032986.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    See identical proteins and their annotated locations for NP_032986.1

    Status: REVIEWED

    Source sequence(s)
    AK138025, BU701098, CK616227, U92437
    Consensus CDS
    CCDS29753.1
    UniProtKB/Swiss-Prot
    O08586
    UniProtKB/TrEMBL
    Q3UUT8
    Related
    ENSMUSP00000013807.7, ENSMUST00000013807.7
    Conserved Domains (2) summary
    pfam10409
    Location:188349
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl25998
    Location:87184
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p6 C57BL/6J

    Range
    32757577..32826160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526769.2XP_006526832.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    Conserved Domains (1) summary
    pfam10409
    Location:55216
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177096.2: Suppressed sequence

    Description
    NM_177096.2: This RefSeq was temporarily suppressed because it is suspected to be 3' UTR sequence of a splice variant of the Pten gene (GeneID:19211).
Support Center