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Ptbp1 polypyrimidine tract binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 19205, updated on 8-Jan-2023

Summary

Official Symbol
Ptbp1provided by MGI
Official Full Name
polypyrimidine tract binding protein 1provided by MGI
Primary source
MGI:MGI:97791
See related
Ensembl:ENSMUSG00000006498 AllianceGenome:MGI:97791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1
Summary
Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome and negative regulation of neuron differentiation. Acts upstream of with a negative effect on gene expression. Acts upstream of or within neurogenesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and sensory organ. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 115.0), limb E14.5 (RPKM 113.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ptbp1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79690266..79700269)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79854432..79864435)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40713 Neighboring gene paralemmin Neighboring gene mitotic spindle positioning Neighboring gene RIKEN cDNA E130317F20 gene Neighboring gene phospholipid phosphatase related 3 Neighboring gene microRNA 6910 Neighboring gene proteinase 3 Neighboring gene elastase, neutrophil expressed

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables regulatory region RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_negative_effect gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of secretory granule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polypyrimidine tract-binding protein 1
Names
heterogeneous nuclear ribonucleoprotein I
hnRNP I

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077363.3NP_001070831.1  polypyrimidine tract-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001070831.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC151846
    Consensus CDS
    CCDS35969.1
    UniProtKB/Swiss-Prot
    Q922I7
    UniProtKB/TrEMBL
    A0A6P5QJ92, A0A8C6G8W8, Q922I7
    Related
    ENSMUSP00000126192.2, ENSMUST00000172282.8
    Conserved Domains (1) summary
    TIGR01649
    Location:56555
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
  2. NM_001283013.2NP_001269942.1  polypyrimidine tract-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001269942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment and an exon in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC151846
    Consensus CDS
    CCDS70064.1
    UniProtKB/TrEMBL
    Q8CB58
    Related
    ENSMUSP00000093109.5, ENSMUST00000095457.11
    Conserved Domains (3) summary
    cd12693
    Location:140235
    RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
    TIGR01649
    Location:36489
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:296388
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001407385.1NP_001394314.1  polypyrimidine tract-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC151846
  4. NM_001407387.1NP_001394316.1  polypyrimidine tract-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC151846
  5. NM_001407389.1NP_001394318.1  polypyrimidine tract-binding protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC151846
  6. NM_001407391.1NP_001394320.1  polypyrimidine tract-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151846
  7. NM_001407393.1NP_001394322.1  polypyrimidine tract-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151846
  8. NM_008956.4NP_032982.2  polypyrimidine tract-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_032982.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC151846
    Consensus CDS
    CCDS35970.1
    UniProtKB/TrEMBL
    A0A6P5QHP3, Q8BGJ5, Q922I7
    Related
    ENSMUSP00000127783.2, ENSMUST00000165704.8
    Conserved Domains (1) summary
    TIGR01649
    Location:56529
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. NR_176355.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151846
  2. NR_176356.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151846
  3. NR_176357.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151846

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79690266..79700269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003948623.2 RNA Sequence

  2. XR_003948622.2 RNA Sequence