U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pipox pipecolic acid oxidase [ Mus musculus (house mouse) ]

Gene ID: 19193, updated on 26-Sep-2022

Summary

Official Symbol
Pipoxprovided by MGI
Official Full Name
pipecolic acid oxidaseprovided by MGI
Primary source
MGI:MGI:1197006
See related
Ensembl:ENSMUSG00000017453 AllianceGenome:MGI:1197006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pso; LPIPOX
Summary
Predicted to enable L-pipecolate oxidase activity and sarcosine oxidase activity. Predicted to be involved in L-lysine catabolic process to acetyl-CoA via L-pipecolate. Located in peroxisome. Is expressed in alimentary system; liver; nervous system; and urinary system. Orthologous to human PIPOX (pipecolic acid and sarcosine oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 95.8), liver adult (RPKM 89.7) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pipox in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77771440..77784698, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77880614..77893872, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin XVIIIA Neighboring gene predicted gene 10277 Neighboring gene predicted gene, 36875 Neighboring gene predicted gene, 29932 Neighboring gene VISTA enhancer mm981 Neighboring gene predicted gene, 29979 Neighboring gene predicted gene 11190

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-pipecolate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-pipecolate oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables L-pipecolate oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables sarcosine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sarcosine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables sarcosine oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal sarcosine oxidase
Names
L-pipecolate oxidase
L-pipecolic acid oxidase
NP_032978.2
XP_011247109.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008952.2NP_032978.2  peroxisomal sarcosine oxidase

    See identical proteins and their annotated locations for NP_032978.2

    Status: VALIDATED

    Source sequence(s)
    AK149488, BB561815, BY708439, U94700
    Consensus CDS
    CCDS25086.1
    UniProtKB/Swiss-Prot
    O55223, Q9D826
    UniProtKB/TrEMBL
    Q3UEJ8
    Related
    ENSMUSP00000017597.5, ENSMUST00000017597.5
    Conserved Domains (2) summary
    TIGR01377
    Location:8388
    soxA_mon; sarcosine oxidase, monomeric form
    pfam13450
    Location:1238
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77771440..77784698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248807.1XP_011247109.1  peroxisomal sarcosine oxidase isoform X1

    Conserved Domains (1) summary
    TIGR01377
    Location:8374
    soxA_mon; sarcosine oxidase, monomeric form