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Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [ Mus musculus (house mouse) ]

Gene ID: 19188, updated on 12-May-2024

Summary

Official Symbol
Psme2provided by MGI
Official Full Name
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)provided by MGI
Primary source
MGI:MGI:1096365
See related
Ensembl:ENSMUSG00000079197 AllianceGenome:MGI:1096365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA28b
Summary
Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including heart; hemolymphoid system; liver; lung; and pancreas. Orthologous to human PSME2 (proteasome activator subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 78.6), duodenum adult (RPKM 27.9) and 27 other tissues See more
Orthologs
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Genomic context

See Psme2 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55824897..55828558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55587440..55591101, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene ER membrane protein complex subunit 9 Neighboring gene STARR-positive B cell enhancer ABC_E5440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56210161-56210270 Neighboring gene ring finger protein 31 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56222707-56223021 Neighboring gene interferon regulatory factor 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to endopeptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
proteasome activator complex subunit 2
Names
11S regulator complex subunit beta
PA28beta
REG-beta
activator of multicatalytic protease subunit 2
protease (prosome, macropain) 28 subunit, beta
proteasome (prosome, macropain) 28 subunit, beta
proteasome activator 28 subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029855.1NP_001025026.1  proteasome activator complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001025026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate transcription initiation site and uses a distinct start codon, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA216967, AA267668, AK012344, BB869062
    Consensus CDS
    CCDS49495.1
    UniProtKB/TrEMBL
    G3X9V0
    Related
    ENSMUSP00000107009.4, ENSMUST00000111378.10
    Conserved Domains (2) summary
    pfam02251
    Location:957
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:88229
    PA28_beta; Proteasome activator pa28 beta subunit
  2. NM_011190.3NP_035320.1  proteasome activator complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_035320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA216967, AK012344, BU563130, BY134400, BY498670, CA536627
    Consensus CDS
    CCDS49494.1
    UniProtKB/Swiss-Prot
    O35562, P97372
    UniProtKB/TrEMBL
    A0A1G5SJA5, Q5SVP3
    Related
    ENSMUSP00000123798.2, ENSMUST00000161807.8
    Conserved Domains (2) summary
    pfam02251
    Location:1266
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:94235
    PA28_beta; Proteasome activator pa28 beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55824897..55828558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)