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Psmc1 protease (prosome, macropain) 26S subunit, ATPase 1 [ Mus musculus (house mouse) ]

Gene ID: 19179, updated on 8-Jan-2023

Summary

Official Symbol
Psmc1provided by MGI
Official Full Name
protease (prosome, macropain) 26S subunit, ATPase 1provided by MGI
Primary source
MGI:MGI:106054
See related
Ensembl:ENSMUSG00000021178 AllianceGenome:MGI:106054
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S4; rpt2; P26s4; Rpt2/S4
Summary
Predicted to enable TBP-class protein binding activity and proteasome-activating activity. Involved in negative regulation of neuron death. Part of proteasome regulatory particle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 65.8), placenta adult (RPKM 52.0) and 28 other tissues See more
Orthologs
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Genomic context

See Psmc1 in Genome Data Viewer
Location:
12 E; 12 50.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100076461..100089623)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100110202..100123364)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 13 Neighboring gene predicted gene, 51957 Neighboring gene malate dehydrogenase 1, NAD (soluble) pseudogene Neighboring gene nrde-2 necessary for RNA interference, domain containing Neighboring gene predicted gene, 36263

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
26S proteasome regulatory subunit 4
Names
26S protease regulatory subunit 4
26S proteasome AAA-ATPase subunit RPT2
proteasome 26S subunit ATPase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008947.3NP_032973.1  26S proteasome regulatory subunit 4

    See identical proteins and their annotated locations for NP_032973.1

    Status: PROVISIONAL

    Source sequence(s)
    AC159243, AC166349
    Consensus CDS
    CCDS36522.1
    UniProtKB/Swiss-Prot
    P62192
    UniProtKB/TrEMBL
    A0A8C6GU58, Q542I9
    Related
    ENSMUSP00000021595.9, ENSMUST00000021595.10
    Conserved Domains (1) summary
    PTZ00361
    Location:1440
    PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    100076461..100089623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)