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pmk-1 Mitogen-activated protein kinase pmk-1 [ Caenorhabditis elegans ]

Gene ID: 191743, updated on 5-Sep-2021

Summary

Gene symbol
pmk-1
Gene description
Mitogen-activated protein kinase pmk-1
Primary source
WormBase:WBGene00004055
Locus tag
CELE_B0218.3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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Genomic context

See pmk-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (8148794..8151266)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mitogen-activated protein kinase pmk-3;Protein kinase domain-containing protein Neighboring gene Mitogen-activated protein kinase pmk-2;Protein kinase domain-containing protein Neighboring gene Amidase domain-containing protein Neighboring gene Protein kinase domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the pmk-1 gene: The pmk-1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription regulator activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in behavioral response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to metal ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyperosmotic response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in p38MAPK cascade IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of defense response to bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nematicide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to superoxide IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Mitogen-activated protein kinase pmk-1
NP_501365.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8148794..8151266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068964.7NP_501365.1  Mitogen-activated protein kinase pmk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501365.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17446
    Conserved Domains (2) summary
    cd07851
    Location:19361
    STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase
    smart00220
    Location:35319
    S_TKc; Serine/Threonine protein kinases, catalytic domain
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