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lin-32 Protein lin-32 [ Caenorhabditis elegans ]

Gene ID: 191703, updated on 6-Jul-2026
Official Symbol
lin-32
Official Full Name
Protein lin-32
Primary source
WormBase:WBGene00003018
Locus tag
CELE_T14F9.5
See related
AllianceGenome:WB:WBGene00003018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein heterodimerization activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of gliogenesis; nematode male tail tip morphogenesis; and neurogenesis. Located in nucleus. Is expressed in several structures, including QL; QL.a; QR; oxygen sensory neurons; and ray precursor cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 89 and persistent hyperplastic primary vitreous. Orthologous to several human genes including ATOH1 (atonal bHLH transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
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See lin-32 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (2229055..2230122, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene uncharacterized protein

Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An atonal homolog, lin-32, regulates hypodermal morphogenesis in Caenorhabditis elegans. Hori S, et al. MicroPubl Biol, 2023. PMID 36873297, Free PMC Article
  2. A transcription factor controlling development of peripheral sense organs in C. elegans. Zhao C, et al. Nature, 1995 Jan 5. PMID 7800042
  3. LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans. Rojo Romanos T, et al. Sci Rep, 2017 Aug 4. PMID 28779171, Free PMC Article
  4. Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans. Masoudi N, et al. Development, 2021 Jun 1. PMID 34100067, Free PMC Article
  5. A proneural gene controls C. elegans neuroblast asymmetric division and migration. Zhu Z, et al. FEBS Lett, 2014 Apr 2. PMID 24589937

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.
    Title: Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.
  2. LIN-32 may promote different target gene expression in neuroblast development.
    Title: A proneural gene controls C. elegans neuroblast asymmetric division and migration.
  3. our results illustrate a mechanism whereby the regulated function of a proneural-class gene in a single neural lineage can both specify a neural precursor and actively pattern the fates of its progeny
    Title: The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell differentiation involved in amphid sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Protein lin-32
NP_508410.2
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2229055..2230122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076009.4 → NP_508410.2  Protein lin-32

    See identical proteins and their annotated locations for NP_508410.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10574
    Conserved Domains (1) summary
    pfam00010
    Location:73 → 124
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10574.2

Gene LinkOut

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