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EEF1A2 eukaryotic translation elongation factor 1 alpha 2 [ Homo sapiens (human) ]

Gene ID: 1917, updated on 19-Sep-2021

Summary

Official Symbol
EEF1A2provided by HGNC
Official Full Name
eukaryotic translation elongation factor 1 alpha 2provided by HGNC
Primary source
HGNC:HGNC:3192
See related
Ensembl:ENSG00000101210 MIM:602959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HS1; STN; EF1A; STNL; DEE33; MRD38; EEF1AL; EIEE33; EF-1-alpha-2
Summary
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]
Expression
Biased expression in heart (RPKM 211.2), brain (RPKM 133.2) and 3 other tissues See more
Orthologs
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Genomic context

See EEF1A2 in Genome Data Viewer
Location:
20q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63488014..63499083, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62119367..62130436, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 2 Neighboring gene uncharacterized LOC105372721 Neighboring gene KCNQ2 antisense RNA 1 Neighboring gene uncharacterized LOC105372725 Neighboring gene uncharacterized LOC102723814

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Epileptic encephalopathy, early infantile, 33
MedGen: C4225337 OMIM: 616409 GeneReviews: Not available
Compare labs
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available
Mental retardation, autosomal dominant 38
MedGen: C4225343 OMIM: 616393 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat EF-1alpha stimulates the binding of RNA Polymerase II and TRP-185 to HIV-1 TAR RNA, suggesting an interaction between EF-1alpha and HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41696

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation factor activity, RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of chaperone-mediated autophagy NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to inorganic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of lysosomal membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
elongation factor 1-alpha 2
Names
eukaryotic elongation factor 1 A-2
statin-S1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034083.1 RefSeqGene

    Range
    5001..16302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001958.5NP_001949.1  elongation factor 1-alpha 2

    See identical proteins and their annotated locations for NP_001949.1

    Status: REVIEWED

    Source sequence(s)
    AL121829
    Consensus CDS
    CCDS13522.1
    UniProtKB/Swiss-Prot
    Q05639
    Related
    ENSP00000217182.3, ENST00000217182.6
    Conserved Domains (1) summary
    PTZ00141
    Location:1460
    PTZ00141; elongation factor 1- alpha; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63488014..63499083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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