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ins-7 Insulin-like peptide 7;putative insulin-like peptide beta-type 4 [ Caenorhabditis elegans ]

Gene ID: 191688, updated on 18-Sep-2024

Summary

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Official Symbol
ins-7
Official Full Name
Insulin-like peptide 7;putative insulin-like peptide beta-type 4
Primary source
WormBase:WBGene00002090
Locus tag
CELE_ZK1251.2
See related
AllianceGenome:WB:WBGene00002090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hormone activity. Involved in olfactory learning. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ins-7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (9682011..9682845, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene ncRNA Neighboring gene Histone H2A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling. Kawli T, et al. Nat Immunol, 2008 Dec. PMID 18854822
  2. Diapause is associated with a change in the polarity of secretion of insulin-like peptides. Matsunaga Y, et al. Nat Commun, 2016 Feb 3. PMID 26838180, Free PMC Article
  3. ins-7 Gene expression is partially regulated by the DAF-16/IIS signaling pathway in Caenorhabditis elegans under celecoxib intervention. Zheng S, et al. PLoS One, 2014. PMID 24945567, Free PMC Article
  4. Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal. Kawano T, et al. Biosci Biotechnol Biochem, 2006 Dec. PMID 17151440
  5. Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan. Mendler M, et al. J Diabetes Complications, 2017 Feb. PMID 27776915

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that, under high glucose conditions, mitochondria-mediated oxidative stress and glycation are downstream targets of ins-7; this impairs neuronal system function and longevity via non-neuronal/neuronal crosstalk by affecting sod-3 and glod-4. (ins-7 = insulin related Probable insulin-like peptide beta-type 4; sod-3 = mitochondrial Mn+2 superoxide dismutase; glod-4 = glyoxalase 1)
    Title: Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
  2. the expression of ins-7, a DAF-16 target gene, was abnormally regulated by celecoxib.
    Title: ins-7 Gene expression is partially regulated by the DAF-16/IIS signaling pathway in Caenorhabditis elegans under celecoxib intervention.
  3. INS-7 secreted from the nervous system functioned in a non-cell autonomous way to activate the insulin pathway and alter basal and inducible expression of immunity-related genes
    Title: Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling.
  4. DAF-16 regulates ins-7 expression in the intestine. Preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues.
    Title: Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.
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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in olfactory learning IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Insulin-like peptide 7;putative insulin-like peptide beta-type 4
NP_001255417.1
  • Confirmed by transcript evidence
NP_001255418.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9682011..9682845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268489.3 → NP_001255418.1  Insulin-like peptide 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255418.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23430
    Conserved Domains (1) summary
    pfam03488
    Location:58 → 105
    Ins_beta; Nematode insulin-related peptide beta type

  2. NM_001268488.3 → NP_001255417.1  putative insulin-like peptide beta-type 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255417.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2S9
    Conserved Domains (1) summary
    pfam03488
    Location:69 → 116
    Ins_beta; Nematode insulin-related peptide beta type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23430.1

Gene LinkOut

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