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ceh-2 Homeobox protein ceh-2 [ Caenorhabditis elegans ]

Gene ID: 191615, updated on 2-Dec-2025
Official Symbol
ceh-2
Official Full Name
Homeobox protein ceh-2
Primary source
WormBase:WBGene00000429
Locus tag
CELE_C27A12.5
See related
AllianceGenome:WB:WBGene00000429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in head; neurons; pharynx; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to several human genes including EMX1 (empty spiracles homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
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See ceh-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (6046788..6050451, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene ncRNA

Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and expression in vitro of a gene encoding tRNAArgACG from the nematode Caenorhabditis elegans. Schaller D, et al. Gene, 1991 Jan 15. PMID 1999292
  2. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Aspöck G, et al. Development, 2003 Aug. PMID 12810585
  3. Gene expression markers for Caenorhabditis elegans vulval cells. Inoue T, et al. Mech Dev, 2002 Dec. PMID 14516686
  4. Caenorhabditis elegans has scores of homoeobox-containing genes. Bürglin TR, et al. Nature, 1989 Sep 21. PMID 2571091
  5. Transcriptional network underlying Caenorhabditis elegans vulval development. Inoue T, et al. Proc Natl Acad Sci U S A, 2005 Apr 5. PMID 15749820, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Homeobox protein ceh-2
NP_491746.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6046788..6050451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059345.7 → NP_491746.1  Homeobox protein ceh-2

    See identical proteins and their annotated locations for NP_491746.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECT8
    Conserved Domains (1) summary
    pfam00046
    Location:130 → 182
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECT8.1

Gene LinkOut

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