U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prx periaxin [ Mus musculus (house mouse) ]

Gene ID: 19153, updated on 8-Feb-2024

Summary

Official Symbol
Prxprovided by MGI
Official Full Name
periaxinprovided by MGI
Primary source
MGI:MGI:108176
See related
Ensembl:ENSMUSG00000053198 AllianceGenome:MGI:108176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L-Periaxin
Summary
Involved in several processes, including myelination in peripheral nervous system; regulation of RNA splicing; and transmission of nerve impulse. Located in cytosol; nuclear speck; and plasma membrane. Is expressed in sciatic nerve. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 29.1), mammary gland adult (RPKM 3.3) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prx in Genome Data Viewer
Location:
7 A3; 7 15.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27198730..27219466)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27499305..27520041)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E107 Neighboring gene predicted gene, 38972 Neighboring gene SERTA domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4910 Neighboring gene predicted gene 15541 Neighboring gene homeodomain interacting protein kinase 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28326448-28326635 Neighboring gene phospholipase D family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28330144-28330331 Neighboring gene RIKEN cDNA 2310022A10 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in peripheral nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system myelin maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peripheral nervous system myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019412.2NP_062285.1  periaxin isoform S

    See identical proteins and their annotated locations for NP_062285.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript but encodes the shorter isoform (S).
    Source sequence(s)
    AC158304, AJ222969, CJ045218
    Consensus CDS
    CCDS39849.1
    UniProtKB/Swiss-Prot
    O55103
    Related
    ENSMUSP00000103992.2, ENSMUST00000108355.2
    Conserved Domains (1) summary
    smart00228
    Location:1798
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  2. NM_198048.2NP_932165.2  periaxin isoform L

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (L).
    Source sequence(s)
    AC158304, AJ222968, CJ045218
    Consensus CDS
    CCDS21023.1
    UniProtKB/TrEMBL
    E9QQ57, Q6NVF7
    Related
    ENSMUSP00000096241.3, ENSMUST00000098644.9
    Conserved Domains (2) summary
    smart00228
    Location:1798
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam02389
    Location:433547
    Cornifin; Cornifin (SPRR) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27198730..27219466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539666.2XP_006539729.1  periaxin isoform X1

    UniProtKB/TrEMBL
    Q6NVF7
    Conserved Domains (2) summary
    smart00228
    Location:1798
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam02389
    Location:434552
    Cornifin; Cornifin (SPRR) family