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Prss12 protease, serine 12 neurotrypsin (motopsin) [ Mus musculus (house mouse) ]

Gene ID: 19142, updated on 19-Jun-2018
Official Symbol
Prss12provided by MGI
Official Full Name
protease, serine 12 neurotrypsin (motopsin)provided by MGI
Primary source
MGI:MGI:1100881
See related
Ensembl:ENSMUSG00000027978 Vega:OTTMUSG00000052551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bssp-3; motopsin
Expression
Broad expression in limb E14.5 (RPKM 5.7), frontal lobe adult (RPKM 5.1) and 20 other tissues See more
Orthologs
See Prss12 in Genome Data Viewer
Location:
3; 3 G1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (123446913..123506602)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (123149831..123209520)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene methyltransferase like 14 Neighboring gene predicted gene, 40143 Neighboring gene predicted gene, 35065 Neighboring gene small nucleolar RNA, H/ACA box 24 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide pseudogene Neighboring gene small nucleolar RNA host gene 8

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
zymogen activation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synaptic cleft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
neurotrypsin
Names
brain-specific serine protease 3
serine protease 12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008939.2NP_032965.1  neurotrypsin precursor

    See identical proteins and their annotated locations for NP_032965.1

    Status: VALIDATED

    Source sequence(s)
    AC110240, AC124005
    Consensus CDS
    CCDS17817.1
    UniProtKB/Swiss-Prot
    O08762
    Related
    ENSMUSP00000029603.8, OTTMUSP00000070384, ENSMUST00000029603.9, OTTMUST00000131751
    Conserved Domains (5) summary
    smart00020
    Location:516755
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:83159
    KR; Kringle domain
    smart00202
    Location:166265
    SR; Scavenger receptor Cys-rich
    cd00190
    Location:517758
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00530
    Location:171265
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    123446913..123506602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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