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ZK287.4 BPTI/Kunitz inhibitor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191282, updated on 7-Sep-2023

Summary

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Gene symbol
ZK287.4
Gene description
BPTI/Kunitz inhibitor domain-containing protein
Primary source
WormBase:WBGene00013965
Locus tag
CELE_ZK287.4
See related
AllianceGenome:WB:WBGene00013965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
14
Sequence:
Chromosome: V; NC_003283.11 (9680134..9685659, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CRC domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-box protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BPTI/Kunitz inhibitor domain-containing protein
NP_001256131.1
  • Confirmed by transcript evidence
NP_001256132.1
  • Confirmed by transcript evidence
NP_001256133.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9680134..9685659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269204.4 → NP_001256133.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23456
    Conserved Domains (4) summary
    smart00131
    Location:1215 → 1259
    KU; BPTI/Kunitz family of serine protease inhibitors
    cd00109
    Location:318 → 369
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:256 → 309
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:45 → 91
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain

  2. NM_001269202.3 → NP_001256131.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256131.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU06
    Conserved Domains (4) summary
    cd00109
    Location:318 → 369
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:256 → 309
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:45 → 91
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00101
    Location:986 → 1030
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  3. NM_001269203.3 → NP_001256132.1  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256132.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU07
    Conserved Domains (4) summary
    cd00109
    Location:318 → 369
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:256 → 309
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:45 → 91
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00101
    Location:1015 → 1059
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Nucleotide Protein
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