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kri-1 human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog [ Caenorhabditis elegans ]

Gene ID: 191275, updated on 19-Aug-2018

Summary

Gene symbol
kri-1
Gene description
human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog
Primary source
WormBase:WBGene00013955
Locus tag
CELE_ZK265.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See kri-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (8226541..8240632, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene COLlagen

Pathways from BioSystems

  • Longevity regulating pathway - worm, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - worm, organism-specific biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Longevity regulating pathway - worm, conserved biosystem (from KEGG)
    Longevity regulating pathway - worm, conserved biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Role of lipid metabolism in C. elegans, organism-specific biosystem (from WikiPathways)
    Role of lipid metabolism in C. elegans, organism-specific biosystem"Lipases regulate life span in C. elegans. Several lipases, K04A8.5, LIPS-7, FIL-1, FIL-2, and ATGL-1, have been demonstrated to influence the lifespan of C. elegans. The figure depicts the mechanism...

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog
NP_001021863.1
  • Confirmed by transcript evidence;
    Product from WormBase gene class kri
NP_001021864.1
  • Confirmed by transcript evidence;
    Product from WormBase gene class kri

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8226541..8240632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026692.3NP_001021863.1  human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021863.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDH0
    Conserved Domains (6) summary
    smart00295
    Location:448645
    B41; Band 4.1 homologues
    cd00204
    Location:305421
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:306401
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:126210
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    sd00045
    Location:305332
    ANK; ANK repeat [structural motif]
    cl09511
    Location:548645
    FERM_B-lobe; FERM domain B-lobe
  2. NM_001026693.3NP_001021864.1  human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF18
    Conserved Domains (6) summary
    smart00295
    Location:448645
    B41; Band 4.1 homologues
    cd00204
    Location:305421
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:306401
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:126210
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    sd00045
    Location:305332
    ANK; ANK repeat [structural motif]
    cl09511
    Location:548645
    FERM_B-lobe; FERM domain B-lobe
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