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Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 19079, updated on 12-May-2024

Summary

Official Symbol
Prkab1provided by MGI
Official Full Name
protein kinase, AMP-activated, beta 1 non-catalytic subunitprovided by MGI
Primary source
MGI:MGI:1336167
See related
Ensembl:ENSMUSG00000029513 AllianceGenome:MGI:1336167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430008F22; 1300015D22Rik
Summary
Predicted to enable protein kinase activity and protein kinase binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within nail development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 43.6), liver E14.5 (RPKM 39.8) and 28 other tissues See more
Orthologs
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Genomic context

See Prkab1 in Genome Data Viewer
Location:
5 F; 5 56.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (116151654..116162449, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (116013586..116024503, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene citron Neighboring gene predicted gene, 42008 Neighboring gene predicted gene, 36185 Neighboring gene STARR-positive B cell enhancer ABC_E2758 Neighboring gene STARR-positive B cell enhancer ABC_E8073 Neighboring gene predicted gene 13842 Neighboring gene transmembrane protein 233

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP-activated protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit beta-1
Names
AMPK subunit beta-1
AMPKb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417558.1NP_001404487.1  5'-AMP-activated protein kinase subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    AC115795
    UniProtKB/Swiss-Prot
    Q91YN6, Q9R078
    UniProtKB/TrEMBL
    Q542K0
    Related
    ENSMUSP00000107630.2, ENSMUST00000111999.8
  2. NM_031869.3NP_114075.1  5'-AMP-activated protein kinase subunit beta-1

    See identical proteins and their annotated locations for NP_114075.1

    Status: VALIDATED

    Source sequence(s)
    AC115795
    Consensus CDS
    CCDS19598.1
    UniProtKB/Swiss-Prot
    Q91YN6, Q9R078
    UniProtKB/TrEMBL
    Q3U5I9, Q542K0
    Related
    ENSMUSP00000031486.8, ENSMUST00000031486.14
    Conserved Domains (2) summary
    smart01010
    Location:181270
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:78159
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

RNA

  1. NR_184530.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115795

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    116151654..116162449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)