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Prep prolyl endopeptidase [ Mus musculus (house mouse) ]

Gene ID: 19072, updated on 26-Sep-2022

Summary

Official Symbol
Prepprovided by MGI
Official Full Name
prolyl endopeptidaseprovided by MGI
Primary source
MGI:MGI:1270863
See related
Ensembl:ENSMUSG00000019849 AllianceGenome:MGI:1270863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PE; PEP; Pop; D10Wsu136e
Summary
Predicted to enable endopeptidase activity; oligopeptidase activity; and peptide binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within protein metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including cranial ganglion; genitourinary system; heart ventricle; thymus primordium; and vibrissa. Orthologous to human PREP (prolyl endopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 28.1), placenta adult (RPKM 26.7) and 28 other tissues See more
Orthologs
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Genomic context

See Prep in Genome Data Viewer
Location:
10 B2; 10 23.27 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (44943312..45038847)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45067216..45162751)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40639 Neighboring gene RIKEN cDNA 2310075K07 gene Neighboring gene VISTA enhancer mm87 Neighboring gene predicted gene, 26016

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables oligopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prolyl endopeptidase
Names
post-proline cleaving enzyme
prolyl oligopeptidase
NP_035286.1
XP_011241444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011156.3NP_035286.1  prolyl endopeptidase

    See identical proteins and their annotated locations for NP_035286.1

    Status: VALIDATED

    Source sequence(s)
    AC153535, AK076257, AK163774, BP759584
    Consensus CDS
    CCDS23826.1
    UniProtKB/Swiss-Prot
    Q80YS1, Q9QUR6
    UniProtKB/TrEMBL
    Q543B9
    Related
    ENSMUSP00000097444.3, ENSMUST00000099858.4
    Conserved Domains (2) summary
    COG1505
    Location:26704
    PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
    pfam00326
    Location:482707
    Peptidase_S9; Prolyl oligopeptidase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    44943312..45038847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243142.3XP_011241444.1  prolyl endopeptidase isoform X1

    Conserved Domains (1) summary
    COG1505
    Location:9477
    PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]