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Ppt1 palmitoyl-protein thioesterase 1 [ Mus musculus (house mouse) ]

Gene ID: 19063, updated on 28-Nov-2021

Summary

Official Symbol
Ppt1provided by MGI
Official Full Name
palmitoyl-protein thioesterase 1provided by MGI
Primary source
MGI:MGI:1298204
See related
Ensembl:ENSMUSG00000028657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPT; CLN1; INCL; C77813; AA960502; D4Ertd184e; 9530043G02Rik
Expression
Ubiquitous expression in testis adult (RPKM 41.9), cerebellum adult (RPKM 27.3) and 28 other tissues See more
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Genomic context

See Ppt1 in Genome Data Viewer
Location:
4 D2.2; 4 57.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122729879..122752968)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122836077..122859175)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (122513485..122536418)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene predicted gene 12873 Neighboring gene CAP, adenylate cyclase-associated protein 1 (yeast) Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene major facilitator superfamily domain containing 2A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Ppt1 gene: The Ppt1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Clone Names

  • MGC107420

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sulfatide binding ISO
Inferred from Sequence Orthology
more info
 
enables thiolester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular macromolecule catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane raft organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein depalmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
palmitoyl-protein thioesterase 1
Names
PPT-1
palmitoyl-protein hydrolase 1
NP_032943.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008917.3NP_032943.2  palmitoyl-protein thioesterase 1 precursor

    See identical proteins and their annotated locations for NP_032943.2

    Status: VALIDATED

    Source sequence(s)
    AK151107, AK169579, CB600397
    Consensus CDS
    CCDS38870.1
    UniProtKB/Swiss-Prot
    O88531
    UniProtKB/TrEMBL
    Q3TEL0, Q3U6J9, Q3U6W3
    Related
    ENSMUSP00000030412.5, ENSMUST00000030412.11
    Conserved Domains (1) summary
    pfam02089
    Location:28306
    Palm_thioest; Palmitoyl protein thioesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    122729879..122752968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_376299.5 RNA Sequence

    Related
    ENSMUST00000120157.2
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