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Inpp5k inositol polyphosphate 5-phosphatase K [ Mus musculus (house mouse) ]

Gene ID: 19062, updated on 18-Apr-2024

Summary

Official Symbol
Inpp5kprovided by MGI
Official Full Name
inositol polyphosphate 5-phosphatase Kprovided by MGI
Primary source
MGI:MGI:1194899
See related
Ensembl:ENSMUSG00000006127 AllianceGenome:MGI:1194899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C62; Pps; SKIP
Summary
Enables inositol bisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and vasopressin receptor activity. Involved in several processes, including negative regulation of phosphate metabolic process; negative regulation of signal transduction; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within glucose homeostasis; in utero embryonic development; and response to insulin. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 44.4), thymus adult (RPKM 36.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 B5; 11 45.92 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75519893..75539691)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75629067..75648865)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931413K12 gene Neighboring gene predicted gene, 53686 Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene Neighboring gene STARR-seq mESC enhancer starr_30001 Neighboring gene STARR-positive B cell enhancer ABC_E3974 Neighboring gene STARR-positive B cell enhancer ABC_E3975 Neighboring gene myosin IC Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol bisphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol bisphosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol bisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables inositol trisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol trisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vasopressin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycogen (starch) synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of renal water transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of urine volume IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inositol polyphosphate 5-phosphatase K
Names
PI-5-phosphatase related
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
phosphatidylinositol-4,5-bisphosphate 5-phosphatase
putative PI-5-phosphatase
skeletal muscle and kidney enriched inositol polyphosphate phosphatase
skeletal muscle and kidney-enriched inositol phosphatase
NP_032942.1
XP_006532570.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008916.2NP_032942.1  inositol polyphosphate 5-phosphatase K

    See identical proteins and their annotated locations for NP_032942.1

    Status: VALIDATED

    Source sequence(s)
    BC066112
    Consensus CDS
    CCDS25053.1
    UniProtKB/Swiss-Prot
    O09040, Q8C5L6
    UniProtKB/TrEMBL
    Q05DI2, Q5ND43
    Related
    ENSMUSP00000006286.3, ENSMUST00000006286.9
    Conserved Domains (2) summary
    pfam17751
    Location:350450
    SKICH; SKICH domain
    cl00490
    Location:32339
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75519893..75539691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532507.4XP_006532570.1  inositol polyphosphate 5-phosphatase K isoform X1

    UniProtKB/TrEMBL
    Q05DI2
    Conserved Domains (2) summary
    pfam17751
    Location:350454
    SKICH; SKICH domain
    cl00490
    Location:32339
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. XR_004936848.1 RNA Sequence

  2. XR_388367.3 RNA Sequence