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Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform [ Mus musculus (house mouse) ]

Gene ID: 19057, updated on 5-Nov-2021

Summary

Official Symbol
Ppp3ccprovided by MGI
Official Full Name
protein phosphatase 3, catalytic subunit, gamma isoformprovided by MGI
Primary source
MGI:MGI:107162
See related
Ensembl:ENSMUSG00000022092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Calnc; PP2BA gamma
Expression
Broad expression in testis adult (RPKM 21.7), frontal lobe adult (RPKM 6.2) and 18 other tissues See more
Orthologs
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Genomic context

See Ppp3cc in Genome Data Viewer
Location:
14; 14 D2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70455314..70526979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70217864..70289536, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (70617705..70689256, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 2 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene predicted gene, 26908 Neighboring gene predicted gene, 33790 Neighboring gene solute carrier family 39 (zinc transporter), member 14 Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Names
CAM-PRP catalytic subunit
calcineurin, testis-specific catalytic subunit
NP_001291920.1
NP_001291921.1
NP_001347158.1
NP_032941.1
XP_006518777.1
XP_017171413.1
XP_030103550.1
XP_030103551.1
XP_036014406.1
XP_036014407.1
XP_036014408.1
XP_036014409.1
XP_036014410.1
XP_036014411.1
XP_036014412.1
XP_036014413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304991.1NP_001291920.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC046617, BY716864
    Consensus CDS
    CCDS88703.1
    UniProtKB/TrEMBL
    Q80XK0
    Related
    ENSMUSP00000153725.2, ENSMUST00000228911.2
    Conserved Domains (2) summary
    smart00156
    Location:54325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  2. NM_001304992.1NP_001291921.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons and uses a downstream start codon compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    BC046617, BC145347, BY716864
    UniProtKB/TrEMBL
    Q80XK0
    Conserved Domains (1) summary
    cl13995
    Location:1173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  3. NM_001360229.1NP_001347158.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139294, AC151836, AK015002, AK133393, BY716864
    Related
    ENSMUST00000228265.2
    Conserved Domains (1) summary
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  4. NM_008915.3NP_032941.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

    See identical proteins and their annotated locations for NP_032941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC139294, AK133393, BC046617, BY716864
    Consensus CDS
    CCDS36968.1
    UniProtKB/Swiss-Prot
    P48455
    UniProtKB/TrEMBL
    Q3V074, Q80XK0
    Related
    ENSMUSP00000077532.7, ENSMUST00000078434.8
    Conserved Domains (2) summary
    smart00156
    Location:54325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70455314..70526979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158519.1XP_036014412.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

    Conserved Domains (1) summary
    cl13995
    Location:14146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  2. XM_036158518.1XP_036014411.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

    Conserved Domains (1) summary
    cl13995
    Location:14146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  3. XM_030247691.2XP_030103551.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X8

    Conserved Domains (1) summary
    cl13995
    Location:14146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  4. XM_036158516.1XP_036014409.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

    Conserved Domains (1) summary
    cl13995
    Location:1173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  5. XM_036158517.1XP_036014410.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

    Conserved Domains (1) summary
    cl13995
    Location:1173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  6. XM_017315924.3XP_017171413.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X8

    Conserved Domains (1) summary
    cl13995
    Location:14146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  7. XM_030247690.2XP_030103550.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6

    Conserved Domains (1) summary
    cl13995
    Location:1173
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  8. XM_036158515.1XP_036014408.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4

    Conserved Domains (1) summary
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  9. XM_036158513.1XP_036014406.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

    Conserved Domains (1) summary
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  10. XM_006518714.5XP_006518777.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2

    Conserved Domains (1) summary
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain
  11. XM_036158520.1XP_036014413.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X9

    Conserved Domains (1) summary
    cl13995
    Location:14146
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  12. XM_036158514.1XP_036014407.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3

    Conserved Domains (1) summary
    cd07416
    Location:37341
    MPP_PP2B; PP2B, metallophosphatase domain

RNA

  1. XR_003950828.2 RNA Sequence

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