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Ppp2r3d protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta [ Mus musculus (house mouse) ]

Gene ID: 19054, updated on 22-May-2024

Summary

Official Symbol
Ppp2r3dprovided by MGI
Official Full Name
protein phosphatase 2 (formerly 2A), regulatory subunit B'', deltaprovided by MGI
Primary source
MGI:MGI:1335093
See related
Ensembl:ENSMUSG00000093803 AllianceGenome:MGI:1335093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR59; Ppp2r3; Ppp2r3a; PP2A PR59; PP2A B''-PR59
Summary
Enables calcium-dependent protein serine/threonine phosphatase activity; chromatin binding activity; and protein phosphatase regulator activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell population proliferation; and protein dephosphorylation. Part of protein phosphatase type 2A complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Ppp2r3d in Genome Data Viewer
Location:
9; 9 F4
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (124195310..124204755)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (124474346..124476862, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 4G Neighboring gene predicted gene, 20783 Neighboring gene RIKEN cDNA 4930526I15 gene

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta
Names
protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
protein phosphatase 2, regulatory subunit (59 kDa)
protein phosphatase 2, regulatory subunit B, alpha
protein phosphatase 2A, 59 kDa regulatory subunit B
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
NP_001156887.1
NP_001392087.1
NP_035284.2
XP_036010587.1
XP_036010589.1
XP_036010590.1
XP_036010591.1
XP_036010592.1
XP_036010593.1
XP_036010594.1
XP_036010595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163415.2NP_001156887.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 1

    See identical proteins and their annotated locations for NP_001156887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    LXEJ02012085
    UniProtKB/TrEMBL
    A0A7N9VRA1, Q8K1A4
    Related
    ENSMUSP00000159447.4, ENSMUST00000239563.3
    Conserved Domains (1) summary
    pfam13499
    Location:343394
    EF-hand_7; EF-hand domain pair
  2. NM_001405158.1NP_001392087.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 2

    Status: VALIDATED

    Source sequence(s)
    LXEJ02012085
  3. NM_011154.2NP_035284.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 2

    See identical proteins and their annotated locations for NP_035284.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK054122, AK143212, BC096544, CB723063, CF735315
    UniProtKB/Swiss-Prot
    Q9Z176
    Related
    ENSMUSP00000140113.3, ENSMUST00000188509.3
    Conserved Domains (1) summary
    cl41751
    Location:71426
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

RNA

  1. NR_028110.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK054122, BC096544
    Related
    ENSMUST00000217354.4
  2. NR_102716.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' exon and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK054122, AK143212, BC096544
    Related
    ENSMUST00000216394.3
  3. NR_175917.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    LXEJ02012085

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    124195310..124204755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154702.1XP_036010595.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X8

    Conserved Domains (1) summary
    cl41751
    Location:2198
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"
  2. XM_036154694.1XP_036010587.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X1

    UniProtKB/TrEMBL
    A0A7N9VRA1
    Conserved Domains (1) summary
    cl41751
    Location:105460
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"
  3. XM_036154700.1XP_036010593.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X7

    Conserved Domains (1) summary
    cl41751
    Location:1319
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"
  4. XM_036154699.1XP_036010592.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X6

    Conserved Domains (1) summary
    cl41751
    Location:1319
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"
  5. XM_036154696.1XP_036010589.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X3

    UniProtKB/Swiss-Prot
    Q9Z176
    Conserved Domains (1) summary
    cl41751
    Location:71426
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"
  6. XM_036154701.1XP_036010594.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X8

    Conserved Domains (1) summary
    cl41751
    Location:2198
    PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"
  7. XM_036154698.1XP_036010591.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X5

    Conserved Domains (1) summary
    cd21504
    Location:157395
    PPP2R3A_B-like; serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins
  8. XM_036154697.1XP_036010590.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X4

    Conserved Domains (1) summary
    cd21504
    Location:157395
    PPP2R3A_B-like; serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins

RNA

  1. XR_004935343.1 RNA Sequence

  2. XR_004935344.1 RNA Sequence

  3. XR_004935345.1 RNA Sequence

  4. XR_004935347.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039134.1: Suppressed sequence

    Description
    NM_001039134.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.