Ppp1cc protein phosphatase 1 catalytic subunit gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1ccprovided by MGI
Official Full Name: protein phosphatase 1 catalytic subunit gammaprovided by MGI
Primary source: MGI:MGI:104872
See related: Ensembl:ENSMUSG00000004455 AllianceGenome:MGI:104872
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP1; PP-1G; dis2m1
Summary: Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Acts upstream of or within regulation of nucleocytoplasmic transport. Located in mitochondrial outer membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human PPP1CC (protein phosphatase 1 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 167.5), CNS E11.5 (RPKM 107.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 F

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122296297..122313336)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122154967..122175273)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction.
Title: Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction.
Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase.
Title: Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase.
The amount of a testis- and sperm-specific isoform of Ppp1cc2 in the chromatin-binding fraction was substantially less in Hspa4l-null spermatozoa than in wild-type mice. Ppp1cc2 was a substrate of Hsc70 and Hsp70. Hspa4l enhanced the release of Ppp1cc2 from these complexes. Ppp1cc2 then localized to chromatin. Ppp1cc2 dephosphorylated protamine 2 at serine 56.
Title: Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.
PP1 promotes dephosphorylation of nNOS serine-852 leading to nitroc oxide and hydrogen peroxide production and endothelium-dependent vasodilation.
Title: Modulation of nNOS(ser852) phosphorylation and translocation by PKA/PP1 pathway in endothelial cells.
These findings provide novel evidence for a role of miRNAs in memory formation and suggest the implication of PP1 in miRNAs processing in the adult brain.
Title: The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner.
NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals.
Title: Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.
The interaction between PPP1CC2 and AKAP4 in human spermatozoa.
Title: Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome.
DNA modification methylase inhibitor 5-aza-2'-deoxycytidine restrains the expression of PP1gamma which is related to learning and memory in mice.
Title: Effects of 5-Aza-2'-deoxycytidine on expression of PP1γ in learning and memory.
Aurkb phosphorylates Oct4(S229) during G2/M phase, leading to the dissociation of Oct4 from chromatin, whereas PP1 binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle.
Title: Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells.
avidity for the substrate plays an important role in imparting specificity on the PPP1R15B-PP1G-actin ternary complex.
Title: G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Ppp1cc gene: The Ppp1cc gene is conserved in rat, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 339 organisms have orthologs with human gene Ppp1cc
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of nucleocytoplasmic transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PTW/PP1 phosphatase complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 1 complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Names: PP1C gamma 1; PP1C gamma 2; protein phosphatase 1C catalytic subunit

NP_038664.2

EC 3.1.3.16

XP_006530263.1

EC 3.1.3.16

XP_036020789.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013636.4 → NP_038664.2 serine/threonine-protein phosphatase PP1-gamma catalytic subunit

See identical proteins and their annotated locations for NP_038664.2

Status: VALIDATED

Source sequence(s)

AC127266

Consensus CDS

CCDS19643.1

UniProtKB/Swiss-Prot

P63087, Q64679

UniProtKB/TrEMBL

Q6ZWM8

Related

ENSMUSP00000099587.5, ENSMUST00000102528.11

Conserved Domains (1) summary

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RNA

NR_156471.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC127266

Related

ENSMUST00000132555.8
NR_156472.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC127266

Related

ENSMUST00000128309.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

122296297..122313336

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530200.4 → XP_006530263.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1

See identical proteins and their annotated locations for XP_006530263.1

UniProtKB/Swiss-Prot

P63087

UniProtKB/TrEMBL

A0A8C6H0T2

Related

ENSMUSP00000083474.7, ENSMUST00000086294.11

Conserved Domains (1) summary

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
XM_036164896.1 → XP_036020789.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2

Related

ENSMUSP00000143146.2, ENSMUST00000197730.2

Conserved Domains (1) summary

cd07414
Location:8 → 263

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain