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Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform [ Mus musculus (house mouse) ]

Gene ID: 19043, updated on 8-Feb-2024

Summary

Official Symbol
Ppm1bprovided by MGI
Official Full Name
protein phosphatase 1B, magnesium dependent, beta isoformprovided by MGI
Primary source
MGI:MGI:101841
See related
Ensembl:ENSMUSG00000061130 AllianceGenome:MGI:101841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP2CB
Summary
Predicted to enable protein serine/threonine phosphatase activity. Involved in N-terminal protein myristoylation and protein dephosphorylation. Located in cytosol and membrane. Is expressed in several structures, including blastocyst; early embryo; gonad; liver; and lung. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 20.4), cerebellum adult (RPKM 16.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ppm1b in Genome Data Viewer
Location:
17 E4; 17 55.13 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (85264169..85331420)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84956741..85023992)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46582 Neighboring gene STARR-seq mESC enhancer starr_43453 Neighboring gene post-GPI attachment to proteins 2 pseudogene Neighboring gene RIKEN cDNA 1110020A21 gene Neighboring gene STARR-seq mESC enhancer starr_43455 Neighboring gene STARR-seq mESC enhancer starr_43456 Neighboring gene STARR-positive B cell enhancer mm9_chr17:85356735-85357036 Neighboring gene STARR-seq mESC enhancer starr_43457 Neighboring gene STARR-positive B cell enhancer ABC_E9445 Neighboring gene solute carrier family 3, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4233 Neighboring gene STARR-seq mESC enhancer starr_43458 Neighboring gene prolyl endopeptidase-like Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene STARR-seq mESC enhancer starr_43460 Neighboring gene STARR-seq mESC enhancer starr_43463 Neighboring gene predicted gene, 36826

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC106489

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cation binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein phosphatase 1B
Names
PP2C-beta
NP_001152968.1
NP_001152969.1
NP_001152970.1
NP_001398498.1
NP_001398499.1
NP_001398500.1
NP_001398501.1
NP_001398502.1
NP_001398503.1
NP_001398505.1
NP_001398506.1
NP_001398507.1
NP_001398508.1
NP_001398509.1
NP_001398510.1
NP_035281.1
XP_006523923.1
XP_011244624.1
XP_036016306.1
XP_036016308.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159496.2NP_001152968.1  protein phosphatase 1B isoform 1

    See identical proteins and their annotated locations for NP_001152968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC142103
    Consensus CDS
    CCDS50199.1
    UniProtKB/TrEMBL
    Q5BKS2, Q99NF7
    Related
    ENSMUSP00000079107.7, ENSMUST00000080217.14
    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  2. NM_001159497.1NP_001152969.1  protein phosphatase 1B isoform 3

    See identical proteins and their annotated locations for NP_001152969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate 5' and 3' UTRs and 3' coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BB615769, BQ176513, D45860
    Consensus CDS
    CCDS50201.1
    UniProtKB/Swiss-Prot
    P36993
    Related
    ENSMUSP00000107924.4, ENSMUST00000112305.10
    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  3. NM_001159498.3NP_001152970.1  protein phosphatase 1B isoform 4

    See identical proteins and their annotated locations for NP_001152970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate 5' and 3' UTRs and 3' coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC142103
    Consensus CDS
    CCDS50200.1
    UniProtKB/Swiss-Prot
    P36993
    Related
    ENSMUSP00000157282.2, ENSMUST00000234540.2
    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  4. NM_001411569.1NP_001398498.1  protein phosphatase 1B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC142103
    UniProtKB/TrEMBL
    Q5BKS2, Q99NF7
  5. NM_001411570.1NP_001398499.1  protein phosphatase 1B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC142103
    UniProtKB/TrEMBL
    Q5BKS2, Q99NF7
  6. NM_001411571.1NP_001398500.1  protein phosphatase 1B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC142103
    UniProtKB/TrEMBL
    Q5BKS2
  7. NM_001411572.1NP_001398501.1  protein phosphatase 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC142103
  8. NM_001411573.1NP_001398502.1  protein phosphatase 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC142103
    Related
    ENSMUSP00000157013.2, ENSMUST00000234332.2
  9. NM_001411574.1NP_001398503.1  protein phosphatase 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC142103
  10. NM_001411576.1NP_001398505.1  protein phosphatase 1B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC142103
    Related
    ENSMUSP00000107926.4, ENSMUST00000112307.4
  11. NM_001411577.1NP_001398506.1  protein phosphatase 1B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC142103
  12. NM_001411578.1NP_001398507.1  protein phosphatase 1B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC142103
  13. NM_001411579.1NP_001398508.1  protein phosphatase 1B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC142103
  14. NM_001411580.1NP_001398509.1  protein phosphatase 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC142103
    UniProtKB/Swiss-Prot
    P36993
    UniProtKB/TrEMBL
    Q546R1, Q5BKS2
  15. NM_001411581.1NP_001398510.1  protein phosphatase 1B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC142103
  16. NM_011151.3NP_035281.1  protein phosphatase 1B isoform 2

    See identical proteins and their annotated locations for NP_035281.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variant 2 uses an alternate 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC142103
    Consensus CDS
    CCDS37710.1
    UniProtKB/Swiss-Prot
    P36993
    UniProtKB/TrEMBL
    Q546R1, Q5BKS2
    Related
    ENSMUSP00000107923.3, ENSMUST00000112304.10
    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RNA

  1. NR_177287.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC142103

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    85264169..85331420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160413.1XP_036016306.1  protein phosphatase 1B isoform X2

    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  2. XM_036160415.1XP_036016308.1  protein phosphatase 1B isoform X3

    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289368
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  3. XM_011246322.3XP_011244624.1  protein phosphatase 1B isoform X1

    See identical proteins and their annotated locations for XP_011244624.1

    UniProtKB/TrEMBL
    Q5BKS2, Q99NF7
    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  4. XM_006523860.4XP_006523923.1  protein phosphatase 1B isoform X1

    See identical proteins and their annotated locations for XP_006523923.1

    UniProtKB/TrEMBL
    Q5BKS2, Q99NF7
    Conserved Domains (2) summary
    cd00143
    Location:23295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain