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Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform [ Mus musculus (house mouse) ]

Gene ID: 19042, updated on 8-Feb-2024

Summary

Official Symbol
Ppm1aprovided by MGI
Official Full Name
protein phosphatase 1A, magnesium dependent, alpha isoformprovided by MGI
Primary source
MGI:MGI:99878
See related
Ensembl:ENSMUSG00000021096 AllianceGenome:MGI:99878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMPa-2; MPPa-1; 2310003C21Rik; 2900017D14Rik
Summary
Enables phosphoprotein phosphatase activity. Involved in N-terminal protein myristoylation. Acts upstream of or within several processes, including negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including Peyer's patch; brain; ganglia; male reproductive gland or organ; and white fat. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.2), cortex adult (RPKM 14.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ppm1a in Genome Data Viewer
Location:
12 C3; 12 30.26 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (72804231..72846593)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (72761211..72799819)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member E, pseudogene 1 Neighboring gene dehydrogenase/reductase 7 like 1 Neighboring gene STARR-seq mESC enhancer starr_32442 Neighboring gene STARR-seq mESC enhancer starr_32443 Neighboring gene dehydrogenase/reductase 7 Neighboring gene STARR-seq mESC enhancer starr_32444 Neighboring gene STARR-seq mESC enhancer starr_32445 Neighboring gene STARR-seq mESC enhancer starr_32447 Neighboring gene STARR-seq mESC enhancer starr_32449 Neighboring gene STARR-seq mESC enhancer starr_32450 Neighboring gene predicted gene, 33785 Neighboring gene STARR-seq mESC enhancer starr_32453 Neighboring gene predicted gene, 40441

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables cation binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in N-terminal protein myristoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1A
Names
Mpp alpha
PP2C-alpha
protein phosphatase IA
NP_032936.1
XP_036013148.1
XP_036013149.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008910.3NP_032936.1  protein phosphatase 1A

    See identical proteins and their annotated locations for NP_032936.1

    Status: VALIDATED

    Source sequence(s)
    AK076054, AV307012, BE861326, BM932496, BY739448, D28117
    Consensus CDS
    CCDS25970.1
    UniProtKB/Swiss-Prot
    P49443
    UniProtKB/TrEMBL
    Q9EQE2
    Related
    ENSMUSP00000021514.9, ENSMUST00000021514.10
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285363
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    72804231..72846593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157255.1XP_036013148.1  protein phosphatase 1A isoform X1

    Conserved Domains (2) summary
    cd00143
    Location:95363
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:357435
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  2. XM_036157256.1XP_036013149.1  protein phosphatase 1A isoform X2

    UniProtKB/Swiss-Prot
    P49443
    UniProtKB/TrEMBL
    Q9EQE2
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285363
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RNA

  1. XR_004937448.1 RNA Sequence

  2. XR_004937449.1 RNA Sequence

  3. XR_004937450.1 RNA Sequence