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Ppic peptidylprolyl isomerase C [ Mus musculus (house mouse) ]

Gene ID: 19038, updated on 12-May-2024

Summary

Official Symbol
Ppicprovided by MGI
Official Full Name
peptidylprolyl isomerase Cprovided by MGI
Primary source
MGI:MGI:97751
See related
Ensembl:ENSMUSG00000024538 AllianceGenome:MGI:97751
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CyP-20c
Summary
Enables peptidyl-prolyl cis-trans isomerase activity. Involved in protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIC (peptidylprolyl isomerase C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 78.7), bladder adult (RPKM 64.9) and 22 other tissues See more
Orthologs
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Genomic context

See Ppic in Genome Data Viewer
Location:
18 D1; 18 29.03 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53539413..53551079, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53406341..53418007, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene sorting nexing 24 Neighboring gene predicted gene, 54042 Neighboring gene predicted gene, 57647 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44622 Neighboring gene STARR-seq mESC enhancer starr_44623 Neighboring gene predicted gene, 41726 Neighboring gene PR domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_44624

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase C
Names
PPIase C
cyclophilin C
rotamase C
NP_032934.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008908.4NP_032934.1  peptidyl-prolyl cis-trans isomerase C precursor

    See identical proteins and their annotated locations for NP_032934.1

    Status: PROVISIONAL

    Source sequence(s)
    AC109291
    Consensus CDS
    CCDS29252.1
    UniProtKB/Swiss-Prot
    P30412
    UniProtKB/TrEMBL
    Q3UC73
    Related
    ENSMUSP00000025419.8, ENSMUST00000025419.9
    Conserved Domains (1) summary
    cd01926
    Location:38197
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    53539413..53551079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)