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S1PR3 sphingosine-1-phosphate receptor 3 [ Homo sapiens (human) ]

Gene ID: 1903, updated on 24-Nov-2021

Summary

Official Symbol
S1PR3provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 3provided by HGNC
Primary source
HGNC:HGNC:3167
See related
Ensembl:ENSG00000213694 MIM:601965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG3; LPB3; S1P3; EDG-3; C9orf47; C9orf108; bA791O21.3
Summary
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 15.3), esophagus (RPKM 10.2) and 24 other tissues See more
Orthologs
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Genomic context

See S1PR3 in Genome Data Viewer
Location:
9q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (88990863..89005155)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91606383..91620070)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12308 Neighboring gene PEST containing nuclear protein pseudogene 2 Neighboring gene SHC adaptor protein 3 Neighboring gene negCOR silencer S5 Neighboring gene Sharpr-MPRA regulatory region 4063

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27140, FLJ37523, FLJ45957, FLJ93220, MGC71696, MGC168509, MGC177970, DKFZp547B028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 3
Names
G protein-coupled receptor, endothelial differentiation gene-3
S1P receptor 3
S1P receptor EDG3
S1P receptor Edg-3
endothelial differentiation G-protein coupled receptor 3
endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
sphingosine 1-phosphate receptor Edg-3
uncharacterized protein C9orf47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395848.1NP_001382777.1  sphingosine 1-phosphate receptor 3

    Status: REVIEWED

    Source sequence(s)
    AL772202
    Conserved Domains (1) summary
    cd15345
    Location:40309
    7tmA_S1PR3_Edg3; sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_005226.4NP_005217.2  sphingosine 1-phosphate receptor 3

    See identical proteins and their annotated locations for NP_005217.2

    Status: REVIEWED

    Source sequence(s)
    BC060827, BM990167, DR763542
    Consensus CDS
    CCDS6680.1
    UniProtKB/Swiss-Prot
    Q99500
    Related
    ENSP00000350878.2, ENST00000358157.3
    Conserved Domains (1) summary
    cd15345
    Location:40309
    7tmA_S1PR3_Edg3; sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_172882.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL772202
  2. NR_172883.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL772202

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    88990863..89005155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001938.4: Suppressed sequence

    Description
    NM_001001938.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  2. NM_001142413.2: Suppressed sequence

    Description
    NM_001142413.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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