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S1PR3 sphingosine-1-phosphate receptor 3 [ Homo sapiens (human) ]

Gene ID: 1903, updated on 11-Sep-2019

Summary

Official Symbol
S1PR3provided by HGNC
Official Full Name
sphingosine-1-phosphate receptor 3provided by HGNC
Primary source
HGNC:HGNC:3167
See related
Ensembl:ENSG00000213694 MIM:601965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG3; LPB3; S1P3; EDG-3
Summary
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 15.3), esophagus (RPKM 10.2) and 24 other tissues See more
Orthologs

Genomic context

See S1PR3 in Genome Data Viewer
Location:
9q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (88991468..89005155)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91606324..91620070)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12308 Neighboring gene PEST containing nuclear protein pseudogene 2 Neighboring gene chromosome 9 open reading frame 47 Neighboring gene SHC adaptor protein 3 Neighboring gene uncharacterized LOC105376136

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37523, FLJ93220, MGC71696

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 3
Names
G protein-coupled receptor, endothelial differentiation gene-3
S1P receptor 3
S1P receptor EDG3
S1P receptor Edg-3
endothelial differentiation G-protein coupled receptor 3
endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
sphingosine 1-phosphate receptor Edg-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005226.4NP_005217.2  sphingosine 1-phosphate receptor 3

    See identical proteins and their annotated locations for NP_005217.2

    Status: REVIEWED

    Source sequence(s)
    BC060827, BM990167, DR763542
    Consensus CDS
    CCDS6680.1
    UniProtKB/Swiss-Prot
    Q99500
    Related
    ENSP00000350878.2, ENST00000358157.3
    Conserved Domains (1) summary
    cd15345
    Location:40309
    7tmA_S1PR3_Edg3; sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    88991468..89005155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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