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Sypl synaptophysin-like protein [ Mus musculus (house mouse) ]

Gene ID: 19027, updated on 8-Nov-2022

Summary

Official Symbol
Syplprovided by MGI
Official Full Name
synaptophysin-like proteinprovided by MGI
Primary source
MGI:MGI:108081
See related
Ensembl:ENSMUSG00000020570 AllianceGenome:MGI:108081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PanI; Pphn; Sypl1; D12Ertd446e
Summary
Located in membrane and secretory granule. Orthologous to human SYPL1 (synaptophysin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 15.7), testis adult (RPKM 11.1) and 28 other tissues See more
Orthologs
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Genomic context

See Sypl in Genome Data Viewer
Location:
12 A3; 12 13.87 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (33003874..33029503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (32953855..32979502)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406C10 gene Neighboring gene coiled-coil domain containing 69 pseudogene Neighboring gene predicted gene, 51998 Neighboring gene predicted gene, 40874 Neighboring gene predicted gene, 24922 Neighboring gene cadherin-related family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptophysin-like protein 1
Names
Pan I
pantophysin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013635.3NP_038663.2  synaptophysin-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_038663.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC155258, BC060971
    Consensus CDS
    CCDS25872.1
    UniProtKB/Swiss-Prot
    O09117, Q8C749
    Related
    ENSMUSP00000075990.6, ENSMUST00000076698.13
    Conserved Domains (1) summary
    pfam01284
    Location:110233
    MARVEL; Membrane-associating domain
  2. NM_198710.3NP_942003.1  synaptophysin-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_942003.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment of the 5' UTR and 5' coding region, compared to variant 1. These differences result in a unique 5' UTR and a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC155258, AK049556, BB847647
    Consensus CDS
    CCDS25873.1
    UniProtKB/Swiss-Prot
    O09117
    UniProtKB/TrEMBL
    Q3TVX7
    Related
    ENSMUSP00000020885.7, ENSMUST00000020885.13
    Conserved Domains (1) summary
    pfam01284
    Location:92215
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    33003874..33029503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243842.3XP_011242144.1  synaptophysin-like protein 1 isoform X1

  2. XM_011243843.3XP_011242145.1  synaptophysin-like protein 1 isoform X2

  3. XM_036157254.1XP_036013147.1  synaptophysin-like protein 1 isoform X3

    Conserved Domains (1) summary
    pfam01284
    Location:181
    MARVEL; Membrane-associating domain