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Ctsa cathepsin A [ Mus musculus (house mouse) ]

Gene ID: 19025, updated on 26-Sep-2022

Summary

Official Symbol
Ctsaprovided by MGI
Official Full Name
cathepsin Aprovided by MGI
Primary source
MGI:MGI:97748
See related
Ensembl:ENSMUSG00000017760 AllianceGenome:MGI:97748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPCA; Ppgb
Summary
This gene encodes a glycoprotein with deamidase, esterase and carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in lung adult (RPKM 116.6), kidney adult (RPKM 99.9) and 27 other tissues See more
Orthologs
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Genomic context

See Ctsa in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164674792..164682952)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164832872..164841032)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene spermatogenesis associated 25 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene phospholipid transfer protein Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene predicted gene, 46775

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of chaperone-mediated autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
lysosomal protective protein
Names
carboxypeptidase C
carboxypeptidase L
protective protein cathepsin A
protective protein for beta-galactosidase
NP_001033581.1
NP_032932.2
XP_030104427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038492.2NP_001033581.1  lysosomal protective protein isoform b preproprotein

    See identical proteins and their annotated locations for NP_001033581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and initiates translation at an alternate downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK019861, AK032197, AL591495, BY319945
    Consensus CDS
    CCDS17062.1
    UniProtKB/Swiss-Prot
    P16675, Q8VEF6
    UniProtKB/TrEMBL
    Q544R6, Q9D2D1
    Related
    ENSMUSP00000099382.4, ENSMUST00000103093.10
    Conserved Domains (1) summary
    pfam00450
    Location:34470
    Peptidase_S10; Serine carboxypeptidase
  2. NM_008906.4NP_032932.2  lysosomal protective protein isoform a preproprotein

    See identical proteins and their annotated locations for NP_032932.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK019861, AK032197, AK159150, AL591495
    Consensus CDS
    CCDS17061.1
    UniProtKB/TrEMBL
    G3X8T3, Q544R6, Q9D2D1
    Conserved Domains (1) summary
    pfam00450
    Location:52488
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164674792..164682952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248567.2XP_030104427.1  lysosomal protective protein isoform X1

    UniProtKB/TrEMBL
    G3X8T3
    Related
    ENSMUSP00000099381.3, ENSMUST00000103092.9
    Conserved Domains (1) summary
    pfam00450
    Location:52488
    Peptidase_S10; Serine carboxypeptidase