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Ppef2 protein phosphatase, EF hand calcium-binding domain 2 [ Mus musculus (house mouse) ]

Gene ID: 19023, updated on 26-Sep-2022

Summary

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Official Symbol
Ppef2provided by MGI
Official Full Name
protein phosphatase, EF hand calcium-binding domain 2provided by MGI
Primary source
MGI:MGI:1342304
See related
Ensembl:ENSMUSG00000029410 AllianceGenome:MGI:1342304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable heat shock protein binding activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and negative regulation of peptidyl-threonine phosphorylation. Predicted to act upstream of or within visual perception. Predicted to be active in cytosol and nucleus. Orthologous to human PPEF2 (protein phosphatase with EF-hand domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Ppef2 in Genome Data Viewer
Location:
5; 5 E2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92374538..92404759, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92226679..92256278, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42113 Neighboring gene cDNA sequence U90926 Neighboring gene predicted gene, 42112 Neighboring gene N-acylethanolamine acid amidase Neighboring gene SDA1 domain containing 1 Neighboring gene predicted gene, 23031

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells. Zwick M, et al. Front Immunol, 2019. PMID 30809231, Free PMC Article
  2. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2). Ramulu P, et al. Mol Cell Biol, 2001 Dec. PMID 11713293, Free PMC Article
  3. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. Sherman PM, et al. Proc Natl Acad Sci U S A, 1997 Oct 14. PMID 9326663, Free PMC Article
  4. Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1. Brunner B, et al. Genome Res, 1999 May. PMID 10330123, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells.
    Title: Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of stimulus involved in sensory perception IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase with EF-hands 2
Names
PPEF-2
NP_035278.1
XP_030110066.1
XP_036020788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011148.5 → NP_035278.1  serine/threonine-protein phosphatase with EF-hands 2

    See identical proteins and their annotated locations for NP_035278.1

    Status: VALIDATED

    Source sequence(s)
    AC125542
    Consensus CDS
    CCDS39151.1
    UniProtKB/Swiss-Prot
    O35385
    Related
    ENSMUSP00000144157.2, ENSMUST00000201130.4
    Conserved Domains (5) summary
    smart00015
    Location:21 → 40
    IQ; Calmodulin-binding motif
    smart00156
    Location:141 → 544
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd00051
    Location:661 → 726
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd07420
    Location:122 → 541
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    pfam13499
    Location:661 → 725
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    92374538..92404759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164895.1 → XP_036020788.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X2

    Conserved Domains (3) summary
    COG5126
    Location:344 → 488
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:424 → 489
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl13995
    Location:12 → 304
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  2. XM_030254206.1 → XP_030110066.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X1

    Related
    ENSMUSP00000031359.9, ENSMUST00000031359.9
    Conserved Domains (4) summary
    smart00015
    Location:61 → 80
    IQ; Calmodulin-binding motif
    COG5126
    Location:621 → 765
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:701 → 766
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd07420
    Location:162 → 581
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35385.1 GenPept UniProtKB/Swiss-Prot:O35385

Gene LinkOut

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