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Med1 mediator complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 19014, updated on 4-Nov-2018

Summary

Official Symbol
Med1provided by MGI
Official Full Name
mediator complex subunit 1provided by MGI
Primary source
MGI:MGI:1100846
See related
Ensembl:ENSMUSG00000018160 Vega:OTTMUSG00000002636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PBP; Pparbp; TRIP-2; CRSP210; DRIP205; TRAP220; AI480703; l11Jus15
Expression
Ubiquitous expression in testis adult (RPKM 9.6), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
Orthologs

Genomic context

See Med1 in Genome Data Viewer
Location:
11 D; 11 61.75 cM
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (98152154..98193314, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98013468..98054607, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 38963 Neighboring gene cyclin-dependent kinase 12 Neighboring gene microRNA 5119

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC90617

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
LBD domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
core promoter binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
mediator complex binding ISO
Inferred from Sequence Orthology
more info
 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
retinoic acid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
thyroid hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
thyroid hormone receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thyroid hormone receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
vitamin D receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vitamin D receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
animal organ regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hepatocyte growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to thyroid hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
enucleate erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell proliferation involved in mammary gland duct elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular steroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland branching involved in pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland branching involved in thelarche IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of G0 to G1 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of RNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of vitamin D receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid hormone generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
transcription initiation from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin ISO
Inferred from Sequence Orthology
more info
 
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
mediator complex ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 1
Names
PPAR-binding protein
Ppar binding protein
TR-interacting protein 2
peroxisome proliferator-activated receptor-binding protein
thyroid hormone receptor-associated protein complex 220 kDa component
thyroid receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080118.1NP_001073587.1  mediator of RNA polymerase II transcription subunit 1 isoform 3

    See identical proteins and their annotated locations for NP_001073587.1

    Status: VALIDATED

    Source sequence(s)
    AK049203, AK054437, AL591205
    Consensus CDS
    CCDS36300.1
    UniProtKB/Swiss-Prot
    Q925J9
    Related
    ENSMUSP00000103169.2, OTTMUSP00000002443, ENSMUST00000107545.8, OTTMUST00000005143
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  2. NM_001361950.1NP_001348879.1  mediator of RNA polymerase II transcription subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK054437, BC079636, CF749368
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  3. NM_001361951.1NP_001348880.1  mediator of RNA polymerase II transcription subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK054437, AW491950, BC079636, CV556361
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  4. NM_013634.2NP_038662.2  mediator of RNA polymerase II transcription subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_038662.2

    Status: VALIDATED

    Source sequence(s)
    AK049203, AL591205, BB846904
    Consensus CDS
    CCDS25341.1
    UniProtKB/Swiss-Prot
    Q925J9
    Related
    ENSMUSP00000018304.5, OTTMUSP00000002444, ENSMUST00000018304.6, OTTMUST00000005144
    Conserved Domains (1) summary
    pfam10744
    Location:45411
    Med1; Mediator of RNA polymerase II transcription subunit 1
  5. NM_134027.2NP_598788.2  mediator of RNA polymerase II transcription subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_598788.2

    Status: VALIDATED

    Source sequence(s)
    AK054437, BC079636
    UniProtKB/Swiss-Prot
    Q925J9
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    98152154..98193314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248799.1XP_011247101.1  mediator of RNA polymerase II transcription subunit 1 isoform X1

    UniProtKB/TrEMBL
    B1AQH6
    Related
    ENSMUSP00000090411.5, OTTMUSP00000002445, ENSMUST00000092735.11, OTTMUST00000005146
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  2. XM_006532504.2XP_006532567.1  mediator of RNA polymerase II transcription subunit 1 isoform X3

    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  3. XM_006532505.2XP_006532568.1  mediator of RNA polymerase II transcription subunit 1 isoform X4

    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  4. XM_006532503.3XP_006532566.1  mediator of RNA polymerase II transcription subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1

RNA

  1. XR_388366.3 RNA Sequence

  2. XR_001779920.1 RNA Sequence

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