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Med1 mediator complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 19014, updated on 18-Apr-2024

Summary

Official Symbol
Med1provided by MGI
Official Full Name
mediator complex subunit 1provided by MGI
Primary source
MGI:MGI:1100846
See related
Ensembl:ENSMUSG00000018160 AllianceGenome:MGI:1100846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PBP; Pparbp; TRIP-2; CRSP210; DRIP205; TRAP220; l11Jus15
Summary
Enables several functions, including promoter-specific chromatin binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cellular response to hepatocyte growth factor stimulus; and regulation of signal transduction. Located in nucleus. Part of mediator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Used to study congestive heart failure and dilated cardiomyopathy. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 9.6), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 D; 11 61.75 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98042980..98084121, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98152154..98193313, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene STARR-positive B cell enhancer ABC_E10712 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:98063825-98064126 Neighboring gene predicted gene, 38963 Neighboring gene cyclin dependent kinase 12 Neighboring gene microRNA 5119

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (11)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90617

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables LBD domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoic acid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear thyroid hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear vitamin D receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear vitamin D receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of G0 to G1 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to thyroid hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within enucleate erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular steroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland branching involved in pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland branching involved in thelarche IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of G0 to G1 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of RNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of vitamin D receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thyroid hormone generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thyroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 1
Names
PPAR-binding protein
Ppar binding protein
TR-interacting protein 2
peroxisome proliferator-activated receptor-binding protein
thyroid hormone receptor-associated protein complex 220 kDa component
thyroid receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080118.2NP_001073587.1  mediator of RNA polymerase II transcription subunit 1 isoform 3

    See identical proteins and their annotated locations for NP_001073587.1

    Status: VALIDATED

    Source sequence(s)
    AL591205
    Consensus CDS
    CCDS36300.1
    UniProtKB/Swiss-Prot
    A2A526, A2A528, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925J9, Q925K0
    Related
    ENSMUSP00000103169.3, ENSMUST00000107545.9
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  2. NM_001361950.2NP_001348879.1  mediator of RNA polymerase II transcription subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591205
    Consensus CDS
    CCDS88244.1
    UniProtKB/TrEMBL
    B1AQH6
    Related
    ENSMUSP00000090411.6, ENSMUST00000092735.12
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  3. NM_001361951.2NP_001348880.1  mediator of RNA polymerase II transcription subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591205
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  4. NM_013634.3NP_038662.2  mediator of RNA polymerase II transcription subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_038662.2

    Status: VALIDATED

    Source sequence(s)
    AL591205
    Consensus CDS
    CCDS25341.1
    UniProtKB/Swiss-Prot
    Q925J9
    Related
    ENSMUSP00000018304.6, ENSMUST00000018304.7
    Conserved Domains (1) summary
    pfam10744
    Location:45411
    Med1; Mediator of RNA polymerase II transcription subunit 1
  5. NM_134027.3NP_598788.2  mediator of RNA polymerase II transcription subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_598788.2

    Status: VALIDATED

    Source sequence(s)
    AL591205
    UniProtKB/Swiss-Prot
    Q925J9
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98042980..98084121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532504.3XP_006532567.1  mediator of RNA polymerase II transcription subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  2. XM_006532505.3XP_006532568.1  mediator of RNA polymerase II transcription subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1

RNA

  1. XR_004936845.1 RNA Sequence

  2. XR_388366.5 RNA Sequence

  3. XR_001779920.3 RNA Sequence