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Pou3f4 POU domain, class 3, transcription factor 4 [ Mus musculus (house mouse) ]

Gene ID: 18994, updated on 27-Nov-2024

Summary

Official Symbol
Pou3f4provided by MGI
Official Full Name
POU domain, class 3, transcription factor 4provided by MGI
Primary source
MGI:MGI:101894
See related
Ensembl:ENSMUSG00000056854 AllianceGenome:MGI:101894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slf; Brn4; Otf9; Brn-4; OTF-9; oct-9
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cochlea morphogenesis and negative regulation of mesenchymal cell apoptotic process. Acts upstream of or within forebrain neuron differentiation; inner ear development; and sensory perception of sound. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; cranium; ear; embryo ectoderm; and foregut-midgut junction. Human ortholog(s) of this gene implicated in X-linked deafness 2. Orthologous to human POU3F4 (POU class 3 homeobox 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Pou3f4 in Genome Data Viewer
Location:
X E1; X 48.2 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (109857985..109862714)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (110814379..110819108)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47765 Neighboring gene baculoviral IAP repeat-containing 6 pseudogene Neighboring gene predicted gene, 26108 Neighboring gene STARR-seq mESC enhancer starr_47766 Neighboring gene STARR-seq mESC enhancer starr_47767 Neighboring gene STARR-seq mESC enhancer starr_47768 Neighboring gene STARR-seq mESC enhancer starr_47769 Neighboring gene STARR-seq mESC enhancer starr_47770 Neighboring gene cylicin, basic protein of sperm head cytoskeleton 1 Neighboring gene developmental pluripotency associated 5 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 
  • Radiation induced (1) 
  • Spontaneous (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
POU domain, class 3, transcription factor 4
Names
brain-4 class III POU-domain protein
brain-specific homeobox/POU domain protein 4
octamer-binding protein 9
octamer-binding transcription factor 9
sex linked fidget

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008901.2NP_032927.1  POU domain, class 3, transcription factor 4

    See identical proteins and their annotated locations for NP_032927.1

    Status: VALIDATED

    Source sequence(s)
    AL672221, BC086670, BC145919, BY309115
    Consensus CDS
    CCDS30355.1
    UniProtKB/Swiss-Prot
    P25216, P62515
    UniProtKB/TrEMBL
    A6H6L6, Q3TYV9
    Related
    ENSMUSP00000077354.4, ENSMUST00000078229.5
    Conserved Domains (2) summary
    smart00352
    Location:186260
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:281335
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    109857985..109862714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)